ATP-binding cassette, subfamily C (CFTR/MRP), member 8
Identifiers
Symbol
ABCC8
Alt. symbols
SUR1
NCBI gene
6833
HGNC
59
OMIM
600509
RefSeq
NM_000352
UniProt
Q09428
Other data
Locus
Chr. 11 p15.1
Search for
Structures
Swiss-model
Domains
InterPro
ATP-binding cassette, subfamily C (CFTR/MRP), member 9
Identifiers
Symbol
ABCC9
Alt. symbols
SUR2A, SUR2B
NCBI gene
10060
HGNC
60
OMIM
601439
RefSeq
NM_005691
UniProt
O60706
Other data
Locus
Chr. 12 p12.1
Search for
Structures
Swiss-model
Domains
InterPro
In molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2).[1] The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel.[2]
Three forms of the sulfonylurea receptor are known, SUR1 encoded by the ABCC8 gene, and SUR2A and SUR2B, which are splice variants arising from a single ABCC9 gene.[3]
molecular biology, the sulfonylureareceptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs...
Sulfonylureas or sulphonylureas are a class of organic compounds used in medicine and agriculture. The functional group consists of a sulfonyl group (-S(=O)2)...
potentiates HGF and IGF-1 actions by the activation of uncoupled sulfonylureareceptor on the plasma membrane of dermal papilla cells. A number of in vitro...
Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is...
have not been fully described. ATP-binding cassette transporter Sulfonylureareceptor GRCh38: Ensembl release 89: ENSG00000006071 – Ensembl, May 2017...
ratio closes the ATP-sensitive SUR1/Kir6.2 potassium channel (see sulfonylureareceptor). This prevents potassium ions (K+) from leaving the cell by facilitated...
ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylureareceptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is...
a sulfonylurea, works by binding to and inhibiting the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylureareceptor 1 (SUR1)...
In the cystic fibrosis transmembrane regulator (CFTR) and in the sulfonylureareceptor (SUR), ATP hydrolysis is associated with the regulation of opening...
of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of...
"Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylureareceptor in pancreatic islets". Biochemical...
technique for analysing multivariate data Sulfonylureareceptor (SUR), the molecular target of sulfonylurea antidiabetic drugs Summer Beaver Airport (IATA...
SUR2 may refer to: Sulfonylureareceptor Sphinganine C4-monooxygenase This disambiguation page lists articles associated with the same title formed as...
Hypoglycemia of Infancy Due to a Dominant Mutation of the β-Cell SulfonylureaReceptor". Jcem.endojournals.org. 2004-09-01. Retrieved 2012-03-10. Umesh...
hypoglycemia is medications used to treat diabetes such as insulin, sulfonylureas, and biguanides. Risk is greater in diabetics who have eaten less than...
Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. It is regarded as...
company Eli Lilly and Company. It is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. It has been shown to achieve a more than 17.5% mean...
glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide, all diabetes...
with other medicines for type 2 diabetes, in particular metformin, sulfonylureas, thiazolidinediones, and insulin taken concomitantly with meals. The...
are similar to sulfonylureas, as they bind to beta cells in the pancreas, but differ by the site of binding to the intended receptor and the drugs' affinities...
Per the British National Formulary it is also less preferred than a sulfonylurea as of 2019, while the American Diabetes Association and European Association...
Tirzepatide is a long-acting GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood-sugar control. Tirzepatide was approved for...
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