sulfide oxidation, using sulfide:quinone oxidoreductase
nitrate assimilation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6821
211389
Ensembl
ENSG00000139531
ENSMUSG00000049858
UniProt
P51687
Q8R086
RefSeq (mRNA)
NM_000456 NM_001032386 NM_001032387
NM_173733
RefSeq (protein)
NP_000447 NP_001027558 NP_001027559
NP_776094
Location (UCSC)
Chr 12: 56 – 56.01 Mb
Chr 10: 128.51 – 128.51 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sulfite oxidase (EC 1.8.3.1) is an enzyme in the mitochondria of all eukaryotes, with exception of the yeasts.[citation needed] It oxidizes sulfite to sulfate and, via cytochrome c, transfers the electrons produced to the electron transport chain, allowing generation of ATP in oxidative phosphorylation.[5][6][7] This is the last step in the metabolism of sulfur-containing compounds and the sulfate is excreted.
Sulfite oxidase is a metallo-enzyme that utilizes a molybdopterin cofactor and a heme group (in the case of animals). It is one of the cytochromes b5 and belongs to the enzyme super-family of molybdenum oxotransferases that also includes DMSO reductase, xanthine oxidase, and nitrite reductase.
In mammals, the expression levels of sulfite oxidase is high in the liver, kidney, and heart, and very low in spleen, brain, skeletal muscle, and blood.
^ abcGRCh38: Ensembl release 89: ENSG00000139531 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049858 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^D'Errico G, Di Salle A, La Cara F, Rossi M, Cannio R (January 2006). "Identification and characterization of a novel bacterial sulfite oxidase with no heme binding domain from Deinococcus radiodurans". J. Bacteriol. 188 (2): 694–701. doi:10.1128/JB.188.2.694-701.2006. PMC 1347283. PMID 16385059.
^Tan WH, Eichler FS, Hoda S, Lee MS, Baris H, Hanley CA, Grant PE, Krishnamoorthy KS, Shih VE (September 2005). "Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature". Pediatrics. 116 (3): 757–66. doi:10.1542/peds.2004-1897. PMID 16140720. S2CID 6506338.
^Cohen HJ, Betcher-Lange S, Kessler DL, Rajagopalan KV (December 1972). "Hepatic sulfite oxidase. Congruency in mitochondria of prosthetic groups and activity". J. Biol. Chem. 247 (23): 7759–66. doi:10.1016/S0021-9258(19)44588-2. PMID 4344230.
Sulfiteoxidase (EC 1.8.3.1) is an enzyme in the mitochondria of all eukaryotes, with exception of the yeasts.[citation needed] It oxidizes sulfite to...
Isolated sulfiteoxidase deficiency is a rare, fatal genetic disease preventing production of sulfiteoxidase, needed to metabolize sulfites to sulfates...
this leads to death within months of birth, due to the lack of active sulfiteoxidase. Furthermore, a mutational block in molybdenum cofactor biosynthesis...
mostly in bacteria. Those enzymes include aldehyde oxidase, sulfiteoxidase and xanthine oxidase. With one exception, Mo in proteins is bound by molybdopterin...
Enzymes in this family include DMSO reductase, xanthine oxidase, nitrite reductase, and sulfiteoxidase. Bioinorganic chemistry * Stephen J. Lippard, Jeremy...
dioxygenase and sulfiteoxidase to oxidize sulfur compounds to sulfate. Reduced sulfur compounds, such as hydrogen sulfide, elemental sulfur, sulfite, thiosulfate...
compounds are converted to sulfite (SO2− 3) and subsequently converted to sulfate (SO2− 4) by the enzyme sulfiteoxidase. Some organisms, however, accomplish...
mostly in bacteria. Those enzymes include aldehyde oxidase, sulfiteoxidase and xanthine oxidase. With one exception, Mo in proteins is bound by molybdopterin...
essential role in cellular respiration. Sulfiteoxidase, a molybdenum-dependent cytochrome, oxidizes sulfite to sulfate. Due to the diverse functions...
that contain the molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfiteoxidase, and nitrate reductase. The only molybdenum-containing...
go to sulfite when absorbed by the lungs, and the sulfite will be converted to sulfate in the liver by an enzyme called sulfiteoxidase. Sulfite can be...
cytochrome as acceptor) Category:EC 1.8.3 (with oxygen as acceptor) Sulfiteoxidase EC 1.8.3.1 Category:EC 1.8.4 (with a disulfide as acceptor) Category:EC...
genetic disease that results in a sulfiteoxidase (a molybdoenzyme) deficiency include increased plasma and urine sulfite, sulfate, thiosulfate, S-sulfocysteine...
the major copper-carrying protein in the blood. Ceruloplasmin exhibits oxidase activity, which is associated with possible oxidation of Fe(II) into Fe(III)...
in fertilized soils. Eukaryotic nitrate reductases are part of the sulfiteoxidase family of molybdoenzymes. They transfer electrons from NADH or NADPH...
different groups of these enzymes are recognized (the xanthine oxidase, sulfiteoxidase (SO) and dimethyl sulfoxide reductase families), and they are present...
which is required for the enzyme activity of sulfiteoxidase, xanthine dehydrogenase/oxidase and aldehyde oxidase. Fosdenopterin was developed at the German...
oxidoreductase, and sulfiteoxidase. This enzyme participates in sulfur metabolism. Charles AM, Suzuki I (1966). "Purification and properties of sulfite:cytochrome...
reduced xanthine oxidase also have been made. Inhibition patterns in the Michaelis complex of low molecular weight hepatic sulfiteoxidase model complex...
converted to sulfite in the mitochondria by thiosulfate reductase, and the sulfite is further oxidized to thiosulfate and sulfate by sulfiteoxidase. The sulfates...
combined deficiency of the MoCo-containing enzymes: sulfiteoxidase, xanthine oxidase, and aldehyde oxidase. Symptoms of MoCo deficiency are linked to the...
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