regulation of interferon-gamma-mediated signaling pathway
signal transduction
interferon-gamma-mediated signaling pathway
cytokine-mediated signaling pathway
microglial cell activation
positive regulation of gene expression
astrocyte activation
negative regulation of amyloid-beta clearance
positive regulation of amyloid-beta formation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3459
15979
Ensembl
ENSG00000027697
ENSMUSG00000020009
UniProt
P15260
P15261
RefSeq (mRNA)
NM_000416 NM_001363526 NM_001363527
NM_010511
RefSeq (protein)
NP_000407 NP_001350455 NP_001350456
NP_034641
Location (UCSC)
Chr 6: 137.2 – 137.22 Mb
Chr 10: 19.47 – 19.49 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000027697 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020009 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry. 262 (18): 8483–7. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953.
^Aguet M, Dembić Z, Merlin G (Oct 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell. 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. S2CID 54247636.
and 16 Related for: Interferon gamma receptor 1 information
heterodimeric receptor consisting of Interferongammareceptor1 (IFNGR1) and Interferongammareceptor 2 (IFNGR2). IFN-γ binding to the receptor activates...
complete deficiency in the interferon-gammareceptor have significant elevations in plasma concentrations of interferon-gamma, which can be measured by...
Interferongammareceptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. This gene (IFNGR2) encodes the non-ligand-binding...
Based on the type of receptor through which they signal, human interferons have been classified into three major types. Interferon type I: All type I IFNs...
Interferon alfa (INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the...
pseudogenes. Interferons bind to interferonreceptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR)...
It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R...
Retinoic acid receptorgamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG...
the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural...
The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to...
(November 1999). "Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferongamma in peripheral human blood mononuclear...
functions are diverse and vary among species but include potentiation of Interferongamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized...
Global Information
