regulation of CD8-positive, alpha-beta T cell proliferation
CD8-positive, alpha-beta T cell differentiation
regulation of innate immune response
negative regulation of regulatory T cell differentiation
regulation of transcription, DNA-templated
cellular response to interferon-beta
interferon-gamma-mediated signaling pathway
immune system process
regulation of adaptive immune response
blood coagulation
regulation of MyD88-dependent toll-like receptor signaling pathway
transcription by RNA polymerase II
transcription, DNA-templated
regulation of cell cycle
positive regulation of transcription, DNA-templated
cellular response to mechanical stimulus
defense response to virus
type I interferon signaling pathway
regulation of immune response
regulation of gene expression
innate immune response
negative regulation of transcription, DNA-templated
positive regulation of type I interferon production
positive regulation of transcription by RNA polymerase II
negative regulation of cell population proliferation
positive regulation of interferon-beta production
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3659
16362
Ensembl
ENSG00000125347
ENSMUSG00000018899
UniProt
P10914
P15314
RefSeq (mRNA)
NM_002198
NM_001159393 NM_001159396 NM_008390
RefSeq (protein)
NP_002189 NP_001341853 NP_001341854
NP_001152865 NP_001152868 NP_032416
Location (UCSC)
n/a
Chr 11: 53.66 – 53.67 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.[4][5]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018899 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Maruyama M, Fujita T, Taniguchi T (Jun 1989). "Sequence of a cDNA coding for human IRF-1". Nucleic Acids Res. 17 (8): 3292. doi:10.1093/nar/17.8.3292. PMC 317732. PMID 2726461.
^Itoh S, Harada H, Nakamura Y, White R, Taniguchi T (Nov 1991). "Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31". Genomics. 10 (4): 1097–9. doi:10.1016/0888-7543(91)90208-V. PMID 1680796.
Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. Interferon regulatory factor 1 was the first member of the interferon...
is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity...
inhibits the activation of several transcription factors (NFκB, ATF4, FOXO1, IRF1, ETS1, and AP-1) which may explain the effect of spilanthol on gene expression...
specific TF according to literature or domain structure – No motif [425] IRF1 ENSG00000125347 IRF Known motif – In vivo/Misc source [426] GAAASTGAAASY...
induce cell death. A more recent study has identified transcription factor IRF1 as the upstream regulator of ZBP1 expression. GRCh38: Ensembl release 89:...
Chromosome 17. While evidence for ‘baseline’ iNOS expression has been elusive, IRF1 and NF-κB-dependent activation of the inducible NOS promoter supports an...
binding sites in the IFN-β promoter due to its sequence similarity with IRF1 and IRF2. However, BLIMP-1 cools down and activates immune responses in a...
activator of transcription 1 (STAT1) and/or Interferon regulatory factor (IRF1) in CD14+ macrophages. HERVs also play various roles shaping the human innate...
transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several...
Sara; Li, Xiaohong; Tang, Miao (November 6, 2017). "HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections"...
organisms other than D. melanogaster, the promoter of the human and mouse IRF1 gene has been found to contain a DPE consensus sequence at the appropriate...
"HDAC8 Promotes Liver Metastasis of Colorectal Cancer via Inhibition of IRF1 and Upregulation of SUCNR1". Oxidative Medicine and Cellular Longevity. 2022:...
transcriptional level of GBP2 is also regulated by two transcription factor STAT1 and IRF1. GBP2 expression have a strong correlation with T cell metagene which seems...
This form of apoptotic activity is inhibited by interaction with viral IRF1. GRIM-19 prevents the transactivation of signal-transducer and activator...
competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription...
expression to advance the disease. IRF8 has been shown to interact with IRF1 and COPS2. Interferon regulatory factors GRCh38: Ensembl release 89: ENSG00000140968...
co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1). Nuclear receptor coactivator 2 has been shown to interact with: AR, ARNT...
activity. In addition, SNX8 enhances the IFNγ-induced activation of the IRF1 promoter in a dose-dependent manner. Specifically, the steps of this pathway...
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