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Start codon information


Start codon (blue circle) of the human mitochondrial DNA MT-ATP6 gene. For each nucleotide triplet (square brackets), the corresponding amino acid is given (one-letter code), either in the +1 reading frame for MT-ATP8 (in red) or in the +3 frame for MT-ATP6 (in blue). In this genomic region, the two genes overlap.

The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome. The start codon always codes for methionine in eukaryotes and archaea and a N-formylmethionine (fMet) in bacteria, mitochondria and plastids.

The start codon is often preceded by a 5' untranslated region (5' UTR). In prokaryotes this includes the ribosome binding site.

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Start codon

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The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome. The start codon always codes for methionine in eukaryotes...

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DNA and RNA codon tables

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methionine—can serve as a start codon and, along with sequences such as an initiation factor, initiates translation. In rare instances, start codons in the standard...

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Stop codon

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In molecular biology, a stop codon (or termination codon) is a codon (nucleotide triplet within messenger RNA) that signals the termination of the translation...

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Genetic code

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within genetic material (DNA or RNA sequences of nucleotide triplets, or codons) into proteins. Translation is accomplished by the ribosome, which links...

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Open reading frame

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reading frames are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic...

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Kozak consensus sequence

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scan past the first AUG site and start initiation at a downstream AUG codon. The ribosome assembles on the start codon (AUG), located within the Kozak...

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Transfer RNA

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machinery of a cell called the ribosome. Complementation of a 3-nucleotide codon in a messenger RNA (mRNA) by a 3-nucleotide anticodon of the tRNA results...

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Ribosome

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anti-codon stem loop. For each coding triplet (codon) in the messenger RNA, there is a unique transfer RNA that must have the exact anti-codon match...

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Eukaryotic translation

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start codon. This process is defined as either cap-dependent, in which the ribosome binds initially at the 5' cap and then travels to the stop codon,...

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Protein biosynthesis

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corresponding to the mRNA codon, in the case of the start codon, this is the amino acid methionine. The next codon (adjacent to the start codon) is then bound by...

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Methionine

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to discriminate against AUG. The methionine codon AUG is also the most common start codon. A "Start" codon is message for a ribosome that signals the initiation...

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Eukaryotic initiation factor

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stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for post-transcription gene regulation. Several...

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Leaky scanning

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the 5'UTR to locate a start codon to commence elongation. Sometimes, the scanning ribosome bypasses the initial AUG start codon and begins translation...

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Point mutation

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termination codon (a stop was lost), resulting in abnormal extension of a protein's carboxyl terminus. Start-gain creates an AUG start codon upstream of...

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Aug

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Steyr AUG, an assault rifle AUG, the most common start codon, the three-nucleotide sequence that starts translation of mRNA and encodes the amino acid methionine...

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Codon degeneracy

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Degeneracy or redundancy of codons is the redundancy of the genetic code, exhibited as the multiplicity of three-base pair codon combinations that specify...

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Messenger RNA

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regions begin with the start codon and end with a stop codon. In general, the start codon is an AUG triplet and the stop codon is UAG ("amber"), UAA ("ochre")...

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Bacterial initiation factor

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followed by mRNA binding, and starts codon-P-site interaction. IF2 enters with the initiator tRNA and places it on the start codon. GTP hydrolysis by IF2 releases...

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Initiation factor

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scanning and selection of the start codons. This can create changes in the selection of the factors, binding to different codons. Another important eukaryotic...

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Five prime untranslated region

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of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript...

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Gene

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Additionally, a "start codon", and three "stop codons" indicate the beginning and end of the protein coding region. There are 64 possible codons (four possible...

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Neutral mutation

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of the affected organism. A Possible start codons in NCBI table 1. ATG is most common. The two other start codons listed by table 1 (GTG and TTG) are rare...

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Nested gene

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entire coding sequence lies within the bounds (between the start codon and the stop codon) of a larger external gene. The coding sequence for a nested...

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