Transfer of spleen or its fragments from one individual to another
Spleen transplantation
ICD-9-CM
41.94
[edit on Wikidata]
Spleen transplantation is the transfer of spleen or its fragments from one individual to another. It is under research for induction of immunological tolerance for other transplanted organs. Success has been achieved in rodent models. Recently, evidence has been obtained for a tolerogenic effect of a spleen transplant in miniature swine.[citation needed] Also, the spleen harbors primitive hematopoietic progenitor cells. Spleen transplantation has been performed on humans with mixed results.[1][2]
^Wu; et al. (January 2011). "Graft-versus-host disease after intestinal and multivisceral transplantation". Transplantation. 91 (2): 219–224. doi:10.1097/tp.0b013e3181ff86ec. PMID 21076376. S2CID 35828611.
^Deierhoi; et al. (April 1986). "Lethal graft-versus-host disease in a recipient of a pancreas-spleen transplant". Transplantation. 41 (4): 544–546. doi:10.1097/00007890-198604000-00028. PMID 3515658.
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