Multinucleated giant cells due to an infection. H&E stain.
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. According to Dr. Bishnu Bhandari, Giant Cells are nothing but the cells that have more than two nucleus. [1]
Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles. Osteoclasts are a type of MGC that are critical for the maintenance, repair, and remodeling of bone and are present normally in a healthy human body. Osteoclasts are frequently classified and discussed separately from other MGCs which are more closely linked with disease.
Non-osteoclast MGCs can arise in response to an infection, such as tuberculosis, herpes, or HIV, or as part of a foreign body reaction. These MGCs are cells of monocyte or macrophage lineage fused together. Similar to their monocyte precursors, they can phagocytose foreign materials. However, their large size and extensive membrane ruffling make them better equipped to clear up larger particles. They utilize activated CR3s to ingest complement-opsonized targets. Non-osteoclast MGCs are also responsible for the clearance of cell debris, which is necessary for tissue remodeling after injuries.[2]
Giantcell arteritis (GCA), also called temporal arteritis, is an inflammatory autoimmune disease of large blood vessels. Symptoms may include headache...
Touton giantcells are a type of multinucleated giantcell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthelasma and...
Langhans giantcells (LGC) are giantcells found in granulomatous conditions. They are formed by the fusion of epithelioid cells (macrophages), and contain...
Tenosynovial giantcell tumor (TGCT) is a group of rare, typically non-malignant tumors of the joints. TGCT tumors often develop from the lining of joints...
Included in this view, are numerous leukocytes, and a multinucleated giantcell. Normal alveolar cytoarchitecture has been obliterated". CDC, Public Health...
identified the cells as part of the nervous system. Langhans giantcell List of distinct cell types in the adult human body Masci, Anna; Arighi, Cecilia...
with are giantcell tumor of bone, osteochondroma, and enchondroma; other forms of benign bone tumors exist but may be less prevalent. Giantcell tumors...
Cytomegalovirus (CMV) (from cyto- 'cell' via Greek κύτος kútos- 'container' + μέγας mégas 'big, megalo-' + -virus via Latin vīrus 'poison') is a genus...
arteritis caused by infection with the fungal pathogen Candida albicans. Giantcell arteritis contains two different types of arteritides that are almost...
include giant-cell tumor of bone, giant-cell tumor of the tendon sheath, and giantcell fibroblastoma. Medicine portal Anaplastic large-cell lymphoma...
peripheral giantcell granuloma. Children are typically mainly affected, with females being affected more than males Diagnosis of giantcell epulis usually...
People who have polymyalgia rheumatica may also have temporal arteritis (giantcell arteritis), an inflammation of blood vessels in the face which can cause...
Subependymal giantcell astrocytoma (SEGA, SGCA, or SGCT) is a low-grade astrocytic brain tumor (astrocytoma) that arises within the ventricles of the...
In pathology, Aschoff cells (or Aschoff giantcells) are cells associated with rheumatic heart disease. They are found in Aschoff bodies surrounding centres...
another, forming aggregates known as giantcells. When examined by transmission electron microscopy in epithelioid cells in the field of Golgi lamellar complex...
identified acantholytic cells, and to diagnose of herpetic infections he identified multinucleated giantcells and acantholytic cells. He extended his cytologic...
juvenile idiopathic arthritis, a severe form of arthritis in children, giantcell arteritis, and COVID‑19. It is a humanized monoclonal antibody against...
Global Information