Micrograph showing nucleated red blood cells (bottom left of image), one of the elements necessary to call extramedullary hematopoiesis, in an endometrial polyp. H&E stain.
Extramedullary hematopoiesis (EMH or sometimes EH[1]) refers to hematopoiesis occurring outside of the medulla of the bone (bone marrow).[2] It can be physiologic or pathologic.
Physiologic EMH occurs during embryonic and fetal development; during this time the main site of fetal hematopoiesis are liver and the spleen.
Pathologic EMH can occur during adulthood when physiologic hematopoiesis can't work properly in the bone marrow and the hematopoietic stem cells (HSC) have to migrate to other tissues in order to continue with the formation of blood cellular components. Pathologic EMH can be caused by myelofibrosis,[3] thalassemias or disorders caused in the hematopoietic system.
^Kim CH (2010-03-23). "Homeostatic and pathogenic extramedullary hematopoiesis". Journal of Blood Medicine. 1: 13–9. doi:10.2147/jbm.s7224. PMC 3262334. PMID 22282679.
^Birbrair A, Frenette PS (April 2016). "Niche heterogeneity in the bone marrow". Annals of the New York Academy of Sciences. 1370 (1): 82–96. Bibcode:2016NYASA1370...82B. doi:10.1111/nyas.13016. PMC 4938003. PMID 27015419.
^Chunduri S, Gaitonde S, Ciurea SO, Hoffman R, Rondelli D (October 2008). "Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation". Haematologica. 93 (10): 1593–5. doi:10.3324/haematol.13203. PMID 18641018.
and 27 Related for: Extramedullary hematopoiesis information
Extramedullaryhematopoiesis (EMH or sometimes EH) refers to hematopoiesis occurring outside of the medulla of the bone (bone marrow). It can be physiologic...
Enlargement of both the liver and spleen Splenomegaly due to extramedullaryhematopoiesis (hematopoiesis occurring outside of the bone marrow) Bone pain Bruising...
severe infection, massive hemorrhage, marrow infiltration, or extramedullaryhematopoiesis. That is, if NRBCs are identified on an adult's complete blood...
fetuses, and sometimes even in adults as well, which leads to extramedullaryhematopoiesis. There is one other sense of myeloid that means "pertaining to...
Blueberry muffin baby, also known as extramedullaryhematopoiesis, describes a newborn baby with multiple purpura, associated with several non-cancerous...
ˌhiːmətoʊ-, ˌhɛmə-/, from Greek αἷμα, 'blood' and ποιεῖν 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation...
common cause is displacement of bone marrow by metastatic cancer (extramedullaryhematopoiesis tends to be modest). Other causes include myeloproliferative...
cells are normally produced in the non-pathological state (see Extramedullaryhematopoiesis for pathological production outside of the bone marrow). These...
level that reduces symptoms of anemia as well as suppresses extramedullaryhematopoiesis which can lead to multiple morbidities. Folic acid supplements...
they may develop into T cells. In the case of fetuses and other extramedullaryhematopoiesis. Hematopoietic stem cells may also settle in the liver or spleen...
[citation needed] Hemolysis caused by the Rh incompatibility, causes extramedullaryhematopoiesis in the fetal liver and bone marrow. The push to make more erythroblasts...
hepatosplenomegaly due to bone expansion leading to bone marrow narrowing and extramedullaryhematopoiesis It can also result in blindness, facial paralysis, and deafness...
atherosclerosis, they accumulate in spleen. This results in extramedullaryhematopoiesis and activating dendritic cell. B1b cells are the most common...
involves the replacement of bone marrow cells by fibrous tissue and extramedullaryhematopoiesis, i.e. the extension of blood cell-forming cells to sites outside...
rare causes of hemothorax include neurofibromatosis type 1 and extramedullaryhematopoiesis. Rarely, hemothoraces can arise due to extrapelvic endometriosis...
Regional Medical Center, a hospital in Elyria, Ohio Extramedullaryhematopoiesis, hematopoiesis occurring outside of the medulla of the bone Elizabeth...
1994). "Gray platelet syndrome with splenomegaly and signs of extramedullaryhematopoiesis: a case report with review of the literature". American Journal...
fetal response to NAIT is variable and may include compensatory extramedullaryhematopoiesis. Rarely, fetal hydrops may develop. Fetal anemia (in presence...
are a major source of morbidity and mortality. Additionally, extramedullaryhematopoiesis can result in liver and spleen dysfunction. Cranial nerve dysfunction...
leads to monocyte production in the spleen in a process called extramedullaryhematopoiesis, which further drives atherosclerosis progression. Showed that...
mostly to the portal hypertension accompanying liver disease with extramedullaryhematopoiesis possibly contributing to the enlargement; accumulation of excessive...
extent of the disease. Dilated and hypertrophied ventricles Extramedullaryhematopoiesis of liver Hypertrophy of myocardium Bright and hyper-reflective...
1994). "Gray platelet syndrome with splenomegaly and signs of extramedullaryhematopoiesis: a case report with review of the literature". Am. J. Hematol...
outside the bone marrow, within the spleen or liver. This is termed extramedullary erythropoiesis. The bone marrow of essentially all the bones produces...
cell cycle progression. TBRG4 is involved in cell proliferation in hematopoiesis and multiple myeloma. TBRG4 shares structural characteristics of the...
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