Synthetic DNA transposon for vertebrate genetic modification
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The Sleeping Beauty transposon system is a synthetic DNA transposon designed to introduce precisely defined DNA sequences into the chromosomes of vertebrate animals for the purposes of introducing new traits and to discover new genes and their functions. It is a Tc1/mariner-type system, with the transposase resurrected from multiple inactive fish sequences.
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The SleepingBeautytransposonsystem is a synthetic DNA transposon designed to introduce precisely defined DNA sequences into the chromosomes of vertebrate...
separate genes in a polycistronic stretch of sequence. The SleepingBeautytransposonsystem (SBTS) is the first successful non-viral vector for incorporation...
resemblance to Drosophila gene nomenclature. SleepingBeautytransposonsystem "Piggybac TransposonSystem". Lonza. Archived from the original on 30 July...
synthetic transposon designed for use in vertebrate (including human) cells, the SleepingBeautytransposonsystem, is a Tc1/mariner-like transposon. Its dead...
insertional mutagenesis research fields. The SleepingBeautytransposonsystem is an example of gene transfer system developed for use in vertebrates. Further...
mutagenesis in mice using the SleepingBeautytransposonsystem. Nat Methods, 2005. 2(10): p. 763-9. Kitada, K., et al., Transposon-tagged mutagenesis in the...
their lifetime, a process known as marbling, which is attributed to a transposon, in which a DNA sequence can change its position within a genome, thereby...
Sistonen L (January 2004). "Nuclear stress granules: the awakening of a sleepingbeauty?". The Journal of Cell Biology. 164 (1): 15–17. doi:10.1083/jcb.200311102...
embryogenesis and developmental biology. Mutants are created by adding transposons into their genomes, or specific genes are deleted by gene targeting....
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