negative regulation of acute inflammatory response
negative regulation of viral entry into host cell
chaperone-mediated protein complex assembly
negative regulation of viral process
negative regulation of glycoprotein metabolic process
protein folding
acute-phase response
negative regulation of exo-alpha-sialidase activity
negative regulation of wound healing
innate immune response
complement activation, classical pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
325
20219
Ensembl
ENSG00000132703
ENSMUSG00000026542
UniProt
P02743
P12246
RefSeq (mRNA)
NM_001639
NM_011318
RefSeq (protein)
NP_001630
NP_035448
Location (UCSC)
Chr 1: 159.59 – 159.59 Mb
Chr 1: 172.72 – 172.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid".[5]APCS is its human gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000132703 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026542 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cathcart ES; Shirahama T; Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophys. Acta. 147 (2): 392–393. doi:10.1016/0005-2795(67)90420-5.
^"Entrez Gene: APCS amyloid P component, serum".
and 25 Related for: Serum amyloid P component information
The serumamyloidPcomponent (SAP) is the identical serum form of the amyloidPcomponent (AP), a 25 kDa pentameric protein first identified as the pentagonal...
this family to be identified. The "short" pentraxins include SerumAmyloidPcomponent (SAP) and C reactive protein (CRP). The "long" pentraxins include...
Serumamyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in...
These deposits often recruit various sugars and other components such as serumamyloidPcomponent, resulting in complex, and sometimes inhomogeneous structures...
Venegas M, Gewurz H, Gewurz AT (September 1988). "Evidence that serumamyloidPcomponent binds to mannose-terminated sequences of polysaccharides and glycoproteins"...
nuclear medicine imaging test which uses iodine-123 (123I) and serumamyloidPcomponent (SAP) to diagnose amyloidosis. In patients with amyloidosis, large...
cells. Cloning of a new gene related to C-reactive protein and serumamyloidPcomponent". The Journal of Biological Chemistry. 267 (31): 22190–7. doi:10...
Lipopolysaccharides directly bind to Hp, which, due to the high abundance of Hp in serum, results in their buffering and shielding from toll-like receptor 4. Functionally...
distribution of the amyloid throughout the body, including the liver, kidney, spleen, and heart. A radiolabelled serumamyloidPcomponent can be administered...
abdomen, and spleen enlargement. Accumulation of amyloid proteins in the liver can lead to elevations in serum aminotransferases and alkaline phosphatase,...
(sacculus) that surrounds the bacterial cytoplasmic membrane. The sugar component consists of alternating residues of β-(1,4) linked N-acetylglucosamine...
decorin, biglycan, fibromodulin and lumican. Proteoglycans are a major component of the animal extracellular matrix, the "filler" substance existing between...
the gastric juice as well as in the gastric mucous membrane. The optimum pH for its action is approximately 7. Its concentration does not correlate with...
characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell...
from milk, contained iron and was structurally and chemically similar to serum transferrin. Therefore, it was named lactoferrin in 1961, though the name...
In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity and to metabolic response...
APCS may refer to: SerumamyloidPcomponent, a human gene AP Computer Science Academics Plus Charter Schools, in Arkansas Avoyelles Public Charter School...
from antibodies to hormones. Glycomics is the study of the carbohydrate components of cells. Though not exclusive to glycoproteins, it can reveal more information...
(1992). "Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts". Endocrinology. 130 (3): 1599–604...
the first component is a beta subunit similar or identical to the beta subunit in activin. However, in contrast to activin, the second component of the inhibin...
that a component of the egg-white was sequestering biotin which Snell verified in vitro using a yeast assay. Snell later isolated the component of egg...
shapes. Along with type-II collagen, aggrecan forms a major structural component of cartilage, particularly articular cartilage. The aggrecan family includes...
Protein C is inhibited by protein C inhibitor.: 369 Protein C is a major component in anticoagulation in the human body. It acts as a serine protease zymogen:...
PMID 11238632. Bharadwaj D, Mold C, Markham E, Du Clos TW (June 2001). "SerumamyloidPcomponent binds to Fc gamma receptors and opsonizes particles for phagocytosis"...
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