positive regulation of cytosolic calcium ion concentration
receptor-mediated endocytosis
neutrophil chemotaxis
platelet activation
macrophage chemotaxis
acute-phase response
lymphocyte chemotaxis
innate immune response
negative regulation of inflammatory response
positive regulation of cell adhesion
regulation of protein secretion
positive chemotaxis
G protein-coupled receptor signaling pathway
cytokine-mediated signaling pathway
cell chemotaxis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6288
20209
Ensembl
ENSG00000173432 ENSG00000288411
ENSMUSG00000057465
UniProt
P0DJI8
P05367
RefSeq (mRNA)
NM_199161 NM_000331 NM_001178006
NM_011314 NM_001357491 NM_001379268 NM_001379269
RefSeq (protein)
NP_000322 NP_001171477 NP_954630
NP_035444 NP_001344420 NP_001366197 NP_001366198
Location (UCSC)
Chr 11: 18.27 – 18.27 Mb
Chr 7: 46.4 – 46.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene.[5][6][7] SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy.[8] When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL).[9] SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis.[10][11]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000057465 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Glaser T, Housman D, Lewis WH, Gerhard D, Jones C (Nov 1989). "A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids". Somatic Cell and Molecular Genetics. 15 (6): 477–501. doi:10.1007/BF01534910. PMID 2595451. S2CID 19607294.
^Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
^"Entrez Gene: SAA1 serum amyloid A1".
^Gabay C, Kushner I (Feb 1999). "Acute-phase proteins and other systemic responses to inflammation". The New England Journal of Medicine. 340 (6): 448–54. doi:10.1056/NEJM199902113400607. PMID 9971870.
^Benditt EP, Eriksen N (Sep 1977). "Amyloid protein SAA is associated with high density lipoprotein from human serum". Proceedings of the National Academy of Sciences of the United States of America. 74 (9): 4025–8. Bibcode:1977PNAS...74.4025B. doi:10.1073/pnas.74.9.4025. PMC 431828. PMID 198813.
^Husebekk A, Skogen B, Husby G, Marhaug G (Mar 1985). "Transformation of amyloid precursor SAA to protein AA and incorporation in amyloid fibrils in vivo". Scandinavian Journal of Immunology. 21 (3): 283–7. doi:10.1111/j.1365-3083.1985.tb01431.x. PMID 3922050. S2CID 29482438.
^Tape C, Tan R, Nesheim M, Kisilevsky R (Sep 1988). "Direct evidence for circulating apoSAA as the precursor of tissue AA amyloid deposits". Scandinavian Journal of Immunology. 28 (3): 317–24. doi:10.1111/j.1365-3083.1988.tb01455.x. PMID 3194701. S2CID 35274998.
SerumamyloidA1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in...
Serumamyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are...
Ikeda Y, Woo P, et al. (November 2002). "Transcriptional regulation of serumamyloidA1 gene expression in human aortic smooth muscle cells involves CCAAT/enhancer...
Serumamyloid A protein is a protein that in humans is encoded by the SAA2 gene. GRCh38: Ensembl release 89: ENSG00000134339 – Ensembl, May 2017 GRCm38:...
amyloidosis where there is depositing of the protein amyloid in the cardiac muscle and surrounding tissues. Amyloid, a misfolded and insoluble protein, can become...
by Apo-AI may rely on a synergistic interaction with alpha-tocopherol. Amyloid deposited in the knee following surgery consists largely of Apo-AI secreted...
Serum response factor, also known as SRF, is a transcription factor protein. Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and...
development of atherosclerotic changes is similar to that in the development of amyloid plaques in the brain and that of age spots on the skin. Misrepair-accumulation...
(1997). "Identification and characterization of glycosylation sites in human serum clusterin". Protein Science. 6 (10): 2120–2133. doi:10.1002/pro.5560061007...
indicated involved in generation and processing of amyloid β (Aβ) peptides. In the brain of the amyloid precursor protein transgenic mice, deletion of ABCA7...
trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease"....
not due to an autoimmune process. Instead, there is an accumulation of amyloid in the pancreatic islets, which likely disrupts their anatomy and physiology...
deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature. Deficiency of vitamin K or antagonism by warfarin...
extracellular amyloid plaques consisting of misfolded amyloid-β protein, b) amyloid-beta precursor protein (which is enzymatically broken down to amyloid-β protein)...
JL, Tung HY, Landers CT, Liu Y, et al. (January 2019). "Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with...
actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target...
amyloidosis and/or inflammation including serumamyloid A (SAA) proteins, a 42-amino acid peptide form amyloid beta termed Aβ42, humanin, and a cleaved...
respectively. The B domain allows Elk1 to bind to a dimer of its cofactor, serum response factor (SRF). Located adjacent to the B domain, the R domain is...
Lazo JS (February 2005). "The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease"....
Membrane glycoproteins Myelin protein zero Osteonectin Protein C Protein S Serumamyloid P component Sialoglycoprotein CD43 Glycophorin Glycophorin C Thrombopoietin...
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