Chemical compound
Selepressin Other names H-Cys(1)-Phe-Ile-hGln-Asn-Cys(1)-Pro-Orn(iPr)-Gly-NH2 ATC code
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-5-(propan-2-ylamino)pentan-2-yl]pyrrolidine-2-carboxamide
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) DTXSID90236538 Formula C 46 H 73 N 13 O 11 S 2 Molar mass 1048 .29 g·mol−1 3D model (JSmol)
CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)Cc2ccccc2)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCCC(=O)N
InChI=1S/C46H73N13O11S2/c1-5-26(4)38-45(69)54-30(14-9-17-35(48)60)41(65)56-32(21-36(49)61)42(66)57-33(24-72-71-23-28(47)39(63)55-31(43(67)58-38)20-27-12-7-6-8-13-27)46(70)59-19-11-16-34(59)44(68)53-29(15-10-18-51-25(2)3)40(64)52-22-37(50)62/h6-8,12-13,25-26,28-34,38,51H,5,9-11,14-24,47H2,1-4H3,(H2,48,60)(H2,49,61)(H2,50,62)(H,52,64)(H,53,68)(H,54,69)(H,55,63)(H,56,65)(H,57,66)(H,58,67)/t26-,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1
Key:JCVQBJTWWDYUFQ-MRUTUVJXSA-N
Selepressin (INN) (code name FE-202158 ), also known as [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin) is a potent, highly selective, short-acting peptide full agonist of the vasopressin 1A receptor and analog of vasopressin which was under development by Ferring Pharmaceuticals for the treatment of vasodilatory hypotension in septic shock.[1] [2] [3] [4]
The Phase 2b/3 adaptive trial (SEPSIS-ACT) was terminated in February 2018 for futility. The trial was halted prior to the initiation of the arm for the highest dosing regimen of 5.0 ng/kg/min.[5]
^ Levin JI (24 October 2014). Macrocycles in Drug Discovery . Royal Society of Chemistry. pp. 313–. ISBN 978-1-84973-701-2 .
^ Vincent JL (23 September 2012). Annual Update in Intensive Care and Emergency Medicine 2012 . Springer Science & Business Media. pp. 80–. ISBN 978-3-642-25716-2 .
^ Vincent JL (2 September 2008). Yearbook of Intensive Care and Emergency Medicine 2008 . Springer Science & Business Media. pp. 427–. ISBN 978-3-540-77290-3 .
^ Laporte R, Kohan A, Heitzmann J, Wisniewska H, Toy J, La E, et al. (June 2011). "Pharmacological characterization of FE 202158, a novel, potent, selective, and short-acting peptidic vasopressin V1a receptor full agonist for the treatment of vasodilatory hypotension". The Journal of Pharmacology and Experimental Therapeutics . 337 (3): 786–96. doi:10.1124/jpet.111.178848. PMID 21411496. S2CID 576654.
^ Clinical trial number NCT02508649 for "Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial" at ClinicalTrials.gov
Last Update: 2023-01-29T13:04:25Z
Selepressin (INN) (code name FE-202158), also known as [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin) is a potent, highly selective, short-acting peptide...
Word Count : 245
Last Update: 2024-03-24T10:12:49Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 3871
Last Update: 2024-06-24T05:30:10Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 11649
Last Update: 2023-11-07T18:20:30Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1518
Last Update: 2024-05-20T07:47:20Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1724
Last Update: 2024-06-20T15:20:25Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 2641
Last Update: 2024-05-15T08:44:09Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 763
Last Update: 2024-03-08T08:21:09Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 584
Last Update: 2023-07-06T09:37:08Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 264
Last Update: 2024-03-10T03:10:57Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 974
Last Update: 2024-05-15T00:01:04Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 2321
Last Update: 2024-05-09T08:21:55Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 2492
Last Update: 2024-02-03T05:27:53Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1913
Last Update: 2016-05-30T05:20:03Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 130
Last Update: 2023-08-27T06:01:00Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1361
Last Update: 2024-01-07T19:46:05Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 3516
Last Update: 2024-03-11T20:29:05Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1714
Last Update: 2024-06-03T05:14:25Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1059
Last Update: 2024-02-11T10:45:52Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1043
Last Update: 2023-12-19T16:33:52Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 126
Last Update: 2023-12-19T16:38:30Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 1682
Last Update: 2024-01-28T23:44:26Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 490
Last Update: 2022-03-27T06:08:19Z
V1A Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan...
Word Count : 407