Tamoxifen, a nonsteroidal triphenylethylene antiestrogen and a widely used drug in the treatment of breast cancer.
Class identifiers
Synonyms
SERM; Estrogen receptor agonist/antagonist; ERAA
Use
Breast cancer, infertility, osteoporosis, vaginal atrophy, dyspareunia, contraception, male hypogonadism, gynecomastia, breast pain, others
ATC code
G03XC
Biological target
Estrogen receptor
Legal status
In Wikidata
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs),[1][2] are a class of drugs that act on the estrogen receptor (ER).[3] A characteristic that distinguishes these substances from pure ER agonists and antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
^Hirsch HD, Shih E, Thacker HL (June 2017). "ERAAs for menopause treatment: Welcome the 'designer estrogens'". Cleve Clin J Med. 84 (6): 463–470. doi:10.3949/ccjm.84a.15140. PMID 28628428.
^Archer DF (August 2020). "Ospemifene: less venous thrombosis than other selective estrogen receptor modulators in postmenopausal women with vulvo vaginal atrophy". Menopause. 27 (8): 846–847. doi:10.1097/GME.0000000000001600. PMID 32576803. S2CID 220045301.
^Riggs BL, Hartmann LC (Feb 2003). "Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice". The New England Journal of Medicine. 348 (7): 618–29. doi:10.1056/NEJMra022219. PMID 12584371.
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