Tamoxifen, a SERMTooltip selective estrogen receptor modulator and a widely used drug in the treatment of breast cancer.
Class identifiers
Synonyms
SRM
Use
Various
Biological target
Steroid hormone receptor
Chemical class
Steroidal; Nonsteroidal
Legal status
In Wikidata
In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.[1] A SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.
^Smith CL, O'Malley BW (February 2004). "Coregulator function: a key to understanding tissue specificity of selective receptor modulators". Endocr. Rev. 25 (1): 45–71. doi:10.1210/er.2003-0023. PMID 14769827.
and 21 Related for: Selective receptor modulator information
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