coreceptor activity involved in Wnt signaling pathway
Wnt-activated receptor activity
coreceptor activity involved in canonical Wnt signaling pathway
Wnt-protein binding
Cellular component
integral component of membrane
Wnt signalosome
Wnt-Frizzled-LRP5/6 complex
membrane
receptor complex
plasma membrane
endoplasmic reticulum
mitochondrion
Biological process
regulation of apoptotic process
positive regulation of osteoblast proliferation
regulation of insulin secretion involved in cellular response to glucose stimulus
endocytosis
limb morphogenesis
extracellular matrix-cell signaling
branching involved in mammary gland duct morphogenesis
somatic stem cell population maintenance
bone marrow development
regulation of canonical Wnt signaling pathway
bone morphogenesis
gastrulation with mouth forming second
embryonic digit morphogenesis
positive regulation of DNA-binding transcription factor activity
cell-cell signaling involved in mammary gland development
cholesterol metabolic process
Wnt signaling pathway
negative regulation of osteoblast differentiation
anatomical structure regression
mammary gland duct morphogenesis
regulation of blood pressure
positive regulation of transcription, DNA-templated
multicellular organism development
retina morphogenesis in camera-type eye
vasculature development
apoptotic process involved in blood vessel morphogenesis
positive regulation of mesenchymal cell proliferation
bone remodeling
Wnt signaling pathway involved in dorsal/ventral axis specification
glucose catabolic process
positive regulation of cell population proliferation
retinal blood vessel morphogenesis
canonical Wnt signaling pathway
osteoblast development
negative regulation of protein serine/threonine kinase activity
adipose tissue development
cell migration involved in gastrulation
cholesterol homeostasis
bone development
positive regulation of fat cell differentiation
positive regulation of mitotic nuclear division
retina vasculature morphogenesis in camera-type eye
anterior/posterior pattern specification
positive regulation of transcription by RNA polymerase II
regulation of bone remodeling
beta-catenin destruction complex disassembly
response to peptide hormone
positive regulation of osteoblast differentiation
toxin transport
Norrin signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4041
16973
Ensembl
ENSG00000162337
ENSMUSG00000024913
UniProt
O75197
Q91VN0
RefSeq (mRNA)
NM_001291902 NM_002335
NM_008513
RefSeq (protein)
NP_001278831 NP_002326
NP_032539
Location (UCSC)
Chr 11: 68.31 – 68.45 Mb
Chr 19: 3.63 – 3.74 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene.[5][6][7] LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis pseudoglioma syndrome with a decrease in bone mass, while a gain-of-function mutation causes drastic increases in bone mass.
^ abcGRCh38: Ensembl release 89: ENSG00000162337 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024913 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hey PJ, Twells RC, Phillips MS, Brown SD, Kawaguchi Y, Cox R, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF (Aug 1998). "Cloning of a novel member of the low-density lipoprotein receptor family". Gene. 216 (1): 103–11. doi:10.1016/S0378-1119(98)00311-4. PMID 9714764.
^Chen D, Lathrop W, Dong Y (Feb 1999). "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human". Genomics. 55 (3): 314–21. doi:10.1006/geno.1998.5688. PMID 10049586.
^"Entrez Gene: LRP5 low density lipoprotein receptor-related protein 5".
the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead...
V, et al. (March 2010). "Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin". Journal of Bone and...
that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway...
specifically more than any of the others. In the body, sclerostin binds to the LRP5 and LRP6 receptors, resulting in inhibition of the Wnt signaling pathway...
LRP5 gene. It is characterized by increased bone density and benign bony structures on the palate. Worth syndrome is caused by a mutation in the LRP5...
it to the proteasome to be digested. However, as soon as Wnt binds Fz and LRP5/6, the destruction complex function becomes disrupted. This is due to Wnt...
sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. Sclerostin, the product of the...
antagonist. More recently, sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signaling pathway. The inhibition of the...
Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, et al. (November 2008). "Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum"...
protein 1 (DKK1). DKK proteins inhibit the Wnt signaling pathway coreceptors LRP5 and LRP6. They bind with high affinity as ligands to KREMEN1 and KREMEN2...
morphogenesis response to retinoic acid negative regulation of Wnt-Frizzled-LRP5/6 complex assembly positive regulation of heart induction by negative regulation...
integrins,[excessive citations] Toll-like receptors (TLRs), Wnt co-receptors LRP5/6, the platelet receptor for the von Willebrand factor, and the latent TGFβ...
non-canonical. The canonical signaling involves binding of Wnt to Frizzled and LRP5 co-receptor, leading to GSK3 phosphorylation and inhibition of β-catenin...
Oculodentodigital dysplasia (ODD) CPLANE1 AR Orofaciodigital syndrome type VI LRP5 AR Osteoporosis-pseudoglioma syndrome PAX2 AD Papillorenal syndrome ATOH7...
PMID 12477932. Hsieh JC, Lee L, Zhang L, et al. (2003). "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity". Cell...
signaling, but upon the binding of a Wnt ligand with a frizzled receptor and Lrp5/6 the 𝜷-catenin signaling molecule is no longer degraded. Instead, it interacts...
membrane, providing a site for Axin and GSK3β to bind and phosphorylate LRP5/6 (transmembrane low-density lipoprotein receptor-related protein), preventing...
Global Information
