LRP6 information

LRP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7
Identifiers
Aliases	LRP6, ADCAD2, STHAG7, LDL receptor related protein 6
External IDs	OMIM: 603507 MGI: 1298218 HomoloGene: 1747 GeneCards: LRP6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,267,044 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	134,543,928 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; liver; ; stromal cell of endometrium; ; ganglionic eminence; ; placenta; ; sural nerve; ; skeletal muscle tissue; ; right lobe of liver; ; myometrium;
	Top expressed in
	ascending aorta; ; aortic valve; ; cumulus cell; ; secondary oocyte; ; extraocular muscle; ; extensor digitorum longus muscle; ; stria vascularis; ; left lung lobe; ; plantaris muscle; ; pineal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	low-density lipoprotein particle receptor activity; apolipoprotein binding; protein homodimerization activity; kinase inhibitor activity; frizzled binding; Wnt-protein binding; toxin transmembrane transporter activity; protein binding; coreceptor activity involved in Wnt signaling pathway; identical protein binding; Wnt-activated receptor activity; signaling receptor binding; coreceptor activity involved in canonical Wnt signaling pathway;
Cellular component	integral component of membrane; Wnt-Frizzled-LRP5/6 complex; Wnt signalosome; Golgi apparatus; early endosome membrane; membrane; receptor complex; synapse; extracellular region; cell surface; neuronal cell body; early endosome; endoplasmic reticulum; caveola; cytoplasmic vesicle; plasma membrane; membrane raft;
Biological process	negative regulation of protein phosphorylation; Wnt signaling pathway involved in somitogenesis; cerebellum morphogenesis; roof of mouth development; dopaminergic neuron differentiation; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; regulation of transcription, DNA-templated; endocytosis; receptor-mediated endocytosis involved in cholesterol transport; embryonic pattern specification; convergent extension; negative regulation of protein kinase activity; thalamus development; axis elongation involved in somitogenesis; canonical Wnt signaling pathway involved in neural crest cell differentiation; positive regulation of cytosolic calcium ion concentration; response to peptide hormone; canonical Wnt signaling pathway involved in regulation of cell proliferation; neural crest cell differentiation; positive regulation of DNA-binding transcription factor activity; Wnt signaling pathway; cellular response to cholesterol; neural crest formation; trachea cartilage morphogenesis; positive regulation of transcription, DNA-templated; odontogenesis of dentin-containing tooth; multicellular organism development; midbrain-hindbrain boundary development; neural tube closure; positive regulation of cell cycle; external genitalia morphogenesis; Wnt signaling pathway involved in dorsal/ventral axis specification; pericardium morphogenesis; cerebral cortex development; embryonic retina morphogenesis in camera-type eye; canonical Wnt signaling pathway; negative regulation of protein serine/threonine kinase activity; protein localization to plasma membrane; negative regulation of canonical Wnt signaling pathway; negative regulation of smooth muscle cell apoptotic process; face morphogenesis; primitive streak formation; positive regulation of transcription by RNA polymerase II; chemical synaptic transmission; toxin transport; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; positive regulation of canonical Wnt signaling pathway; beta-catenin destruction complex disassembly; midbrain dopaminergic neuron differentiation; gastrulation with mouth forming second; anterior/posterior pattern specification; embryonic limb morphogenesis; midbrain development; bone remodeling; embryonic camera-type eye morphogenesis; bone morphogenesis; branching involved in mammary gland duct morphogenesis; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	4040
	16974
	ENSG00000070018; ENSG00000281324
	ENSMUSG00000030201
	O75581
	O88572
	NM_002336
	NM_008514
	NP_002327
	NP_032540
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene.^[5]^[6] LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

^ ^a ^b ^c ENSG00000281324 GRCh38: Ensembl release 89: ENSG00000070018, ENSG00000281324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030201 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021.
^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6".

[refGRCh38Ensembl-1] ENSG00000281324 GRCh38: Ensembl release 89: ENSG00000070018, ENSG00000281324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030201 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9704021-5] Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021.

[entrez-6] "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6".

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