Protein-coding gene in the species Homo sapiens
SPTAN1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FOT, 3F31, 3FB2
Identifiers Aliases SPTAN1 , EIEE5, NEAS, SPTA2, spectrin alpha, non-erythrocytic 1, DEE5External IDs OMIM: 182810; MGI: 98386; HomoloGene: 2353; GeneCards: SPTAN1; OMA:SPTAN1 - orthologs Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,552,558 bp[1] End 128,633,662 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 20.93 cM Start 29,855,572 bp[2] End 29,921,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 amygdala right uterine tube nucleus accumbens prefrontal cortex Brodmann area 10 cingulate gyrus tibial nerve
Top expressed in facial motor nucleus epithelium of lens dentate gyrus of hippocampal formation granule cell ciliary body Rostral migratory stream cerebellar cortex iris anterior horn of spinal cord barrel cortex external carotid artery
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
calcium ion binding
metal ion binding
calmodulin binding
structural constituent of cytoskeleton
protein binding
actin binding
cadherin binding
Cellular component
cytoplasm
extracellular vesicle
cytosol
spectrin
membrane
intracellular membrane-bounded organelle
microtubule cytoskeleton
cell cortex
extracellular exosome
cytoskeleton
extracellular region
specific granule lumen
tertiary granule lumen
Biological process
MAPK cascade
axon guidance
endoplasmic reticulum to Golgi vesicle-mediated transport
actin filament capping
cytoskeleton organization
neutrophil degranulation
regulation of molecular function
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001130438 NM_001195532 NM_003127 NM_001363759 NM_001363765 NM_001375310 NM_001375311 NM_001375312 NM_001375313 NM_001375314 NM_001375318
NM_001076554 NM_001177667 NM_001177668 NM_001309460 NM_001369325
RefSeq (protein) NP_001123910 NP_001182461 NP_003118 NP_001350688 NP_001350694 NP_001362239 NP_001362240 NP_001362241 NP_001362242 NP_001362243 NP_001362247
NP_001171138 NP_001171139 NP_001296389 NP_001356254
Location (UCSC) Chr 9: 128.55 – 128.63 Mb Chr 2: 29.86 – 29.92 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Alpha II-spectrin , also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene.[5] [6] [7] Alpha II-spectrin is expressed in a variety of tissues, and is highly expressed in cardiac muscle at Z-disc structures, costameres and at the sarcolemma membrane. Mutations in alpha II-spectrin have been associated with early infantile epileptic encephalopathy-5, and alpha II-spectrin may be a valuable biomarker for Guillain–Barré syndrome and infantile congenital heart disease.
^ a b c GRCh38: Ensembl release 89: ENSG00000197694 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Leto TL, Fortugno-Erikson D, Barton D, Yang-Feng TL, Francke U, Harris AS, Morrow JS, Marchesi VT, Benz EJ (February 1988). "Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species". Mol Cell Biol . 8 (1): 1–9. doi:10.1128/MCB.8.1.1. PMC 363070 . PMID 3336352.
^ Leto, T. L.; Fortugno-Erikson, D.; Barton, D.; Yang-Feng, T. L.; Francke, U.; Harris, A. S.; Morrow, J. S.; Marchesi, V. T.; Benz, E. J. (1988). "Entrez Gene: SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)". Molecular and Cellular Biology . 8 (1): 1–9. doi:10.1128/MCB.8.1.1. PMC 363070 . PMID 3336352.
^ McMahon AP, Giebelhaus DH, Champion JE, Bailes JA, Lacey S, Carritt B, Henchman SK, Moon RT (1987). "cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin". Differentiation . 34 (1): 68–78. doi:10.1111/j.1432-0436.1987.tb00052.x. PMID 3038643.
Last Update: 2023-11-08T09:07:55Z
Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. Alpha II-spectrin is expressed in a variety of tissues, and is highly...
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Last Update: 2024-04-03T19:42:49Z
Vimentin has been shown to interact with: DSP MEN1 MYST2 PKN1 PRKCI PLEC SPTAN1 UPP1 YWHAZ The 3' UTR of Vimentin mRNA has been found to bind a 46kDa protein...
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Last Update: 2024-02-22T06:58:08Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 7838
Last Update: 2024-05-27T06:34:30Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 5121
Last Update: 2024-06-14T22:55:56Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 3650
Last Update: 2024-06-15T17:16:37Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 2785
Last Update: 2024-05-21T07:41:08Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 3016
Last Update: 2024-01-31T13:06:08Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 2198
Last Update: 2024-05-03T11:42:54Z
syndrome. It can be associated with mutations in ARX, CDKL5, SLC25A22, STXBP1, SPTAN1 , KCNQ2, ARHGEF9, PCDH19, PNKP, SCN2A, PLCB1, SCN8A, ST3GAL3, TBC1D24, BRAT1...
Word Count : 1472
Last Update: 2024-04-20T07:37:29Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 2154
Last Update: 2023-08-31T18:37:41Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 346
Last Update: 2024-06-02T00:07:56Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 4670
Last Update: 2024-03-10T09:37:14Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 779
Last Update: 2023-09-10T18:54:03Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 73
Last Update: 2023-12-15T21:33:01Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 1172
Last Update: 2024-04-01T06:52:41Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 2655
Last Update: 2024-06-07T15:40:27Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 3300
Last Update: 2024-05-06T03:07:45Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 1136
Last Update: 2024-04-19T20:38:51Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 631
Last Update: 2023-12-03T16:08:01Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 3313
Last Update: 2024-06-10T06:39:34Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 4896
Last Update: 2023-10-15T18:04:10Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 1711
Last Update: 2024-04-25T14:29:26Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 3168
Last Update: 2024-04-26T06:22:51Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 6277
Last Update: 2023-12-31T16:37:07Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 974
Last Update: 2024-05-10T22:45:07Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 2464
Last Update: 2021-09-18T16:41:42Z
Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin...
Word Count : 868