Not to be confused with ribonuclease T1 or ribonuclease T2.
Ribonuclease T
A ribonuclease T dimer in complex with DNA (orange), from PDB ID 3NH1.[1]
Identifiers
Symbol
rnt
Pfam
PF00929
InterPro
IPR013520
SMART
SM00479
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Ribonuclease T (RNase T, exonuclease T, exo T) is a ribonuclease enzyme involved in the maturation of transfer RNA and ribosomal RNA in bacteria,[2] as well as in DNA repair pathways.[3] It is a member of the DnaQ family of exonucleases and non-processively acts on the 3' end of single-stranded nucleic acids. RNase T is capable of cleaving both DNA and RNA, with extreme sequence specificity discriminating against cytosine at the 3' end of the substrate.[1][2]
^ abHsiao YY, Duh Y, Chen YP, Wang YT, Yuan HS (September 2012). "How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes". Nucleic Acids Research. 40 (16): 8144–54. doi:10.1093/nar/gks548. PMC 3439924. PMID 22718982.
^ abZuo Y, Deutscher MP (August 2002). "The physiological role of RNase T can be explained by its unusual substrate specificity". The Journal of Biological Chemistry. 277 (33): 29654–61. doi:10.1074/jbc.M204252200. PMID 12050169.
^Hsiao YY, Fang WH, Lee CC, Chen YP, Yuan HS (March 2014). "Structural insights into DNA repair by RNase T--an exonuclease processing 3' end of structured DNA in repair pathways". PLOS Biology. 12 (3): e1001803. doi:10.1371/journal.pbio.1001803. PMC 3942315. PMID 24594808.
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