Not to be confused with ribonuclease T or ribonuclease T1.
Ribonuclease T2
Identifiers
EC no.
3.1.27.1
CAS no.
37278-25-4
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Search
PMC
articles
PubMed
articles
NCBI
proteins
Ribonuclease T2 (EC 3.1.27.1, acid ribonuclease, acid RNase, base-non-specific ribonuclease, Escherichia coli ribonuclease I' ribonuclease PP2, Escherichia coli ribonuclease II, non-base specific ribonuclease, nonbase-specific RNase, nonspecific RNase, ribonnuclease (non-base specific), ribonuclease (non-base specific), ribonuclease II, ribonuclease M, ribonuclease N2, ribonuclease PP3, ribonuclease U4, ribonucleate 3'-oligonucleotide hydrolase, ribonucleate nucleotido-2'-transferase (cyclizing), RNAase CL, RNase (non-base specific), RNase II, RNase M, RNase Ms, RNase T2, ) is an enzyme.[1][2][3][4] It is a type of endoribonuclease. This enzyme catalyses the following chemical reaction
Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates
^García-Segura JM, Orozco MM, Fominaya JM, Gavilanes JG (July 1986). "Purification, molecular and enzymic characterization of an acid RNase from the insect Ceratitis capitata". European Journal of Biochemistry. 158 (2): 367–72. doi:10.1111/j.1432-1033.1986.tb09760.x. PMID 3732273.
^Heppel LA, Davies DR (1966). "Pig liver nuclei ribonuclease". In Cantoni GL (ed.). Procedures in Nucleic Acid Research. New York: Procedures in Nucleic Acid Research. pp. 31–36.
^Reddi KK, Mauser LJ (March 1965). "Studies on the formation of tobacco mosaic virus ribonucleic acid. VI. Mode of degradation of host ribonucleic acid to ribonucleosides and their conversion to ribonucleoside 5′-phosphates". Proceedings of the National Academy of Sciences of the United States of America. 53 (3): 607–13. doi:10.1073/pnas.53.3.607. PMC 336984. PMID 14338240.
^Uchida T, Egami F (January 1967). "The specificity of ribonuclease T2". Journal of Biochemistry. 61 (1): 44–53. doi:10.1093/oxfordjournals.jbchem.a128519. PMID 6048969.
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development. ACTIBIND as an Antiangiogenic ACTIBIND, an extracellular ribonuclease (T2-RNase), has been researched heavily in biochemical laboratories due...
PMC 2662391. PMID 19246759. Luhtala, N.; Parker, R. (2010). "T2 Family ribonucleases: Ancient enzymes with diverse roles". Trends in Biochemical Sciences...
biochemistry, an endoribonuclease is a class of enzyme which is a type of ribonuclease (an RNA cleaver), itself a type of endonuclease (a nucleotide cleaver)...
identifiable protein domains, possibly acquired from the host. PSCNV encodes ribonucleaseT2, two fibronectin type II domains, and three ankyrin repeats. PSCNV...
employed programmed CRISPR/Cas9 knockout of the gene encoding the T2ribonuclease of the egg of Schistosoma mansoni, advancing functional genomics and...
an autocatalytic ribozyme, and Sidney Altman's report of catalysis by ribonuclease P RNA, several other catalytic RNAs were identified in the late 1980s...
mRNAs by base-pairing with complementary sequences and facilitating ribonuclease cleavage by RNase III. It was recently shown that bacteria also have...
C, et al. (1994). "A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues". Science. 266 (5183): 243–7. Bibcode:1994Sci...
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