negative regulation of smooth muscle cell proliferation
negative regulation of translation
activation of protein kinase B activity
response to hypoxia
positive regulation of endothelial cell proliferation
placenta development
rRNA transcription
activation of phospholipase C activity
activation of phospholipase A2 activity
diacylglycerol biosynthetic process
multicellular organism development
cell communication
actin filament polymerization
oocyte maturation
angiogenesis
positive regulation of protein secretion
ovarian follicle development
response to hormone
positive regulation of phosphorylation
adherens junction organization
cell migration
homeostatic process
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis
innate immune response
antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
283
11727
Ensembl
ENSG00000214274
ENSMUSG00000072115
UniProt
P03950
P21570
RefSeq (mRNA)
NM_001145 NM_001097577
NM_001161731 NM_007447
RefSeq (protein)
NP_001091046 NP_001136
NP_001155203 NP_031473
Location (UCSC)
Chr 14: 20.68 – 20.7 Mb
Chr 14: 51.33 – 51.34 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene.[5] Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA.[6][7] Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.[6][8][9]
^ abcGRCh38: Ensembl release 89: ENSG00000214274 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000072115 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gao X, Xu Z (2008). "Mechanisms of action of angiogenin". Acta Biochimica et Biophysica Sinica. 40 (7): 619–624. doi:10.1111/j.1745-7270.2008.00442.x. PMID 18604453. S2CID 32714925.
^ abTello-Montoliu A., Patel J.V., Lip G.Y.H. (2006). "Angiogenin: a review of the pathophysiology and potential clinical applications". Journal of Thrombosis and Haemostasis. 4 (9): 1864–74. doi:10.1111/j.1538-7836.2006.01995.x. PMID 16961595.
^Xu Z, Tsuji T, Riordan J, Hu G (2003). "Identification and characterization of an angiogenin-binding DNA sequence that stimulate luciferase reporter gene expression". Biochemistry. 42 (1): 121–128. doi:10.1021/bi020465x. PMID 12515546.
^Li S, Yu W, Hu GF (2012). "Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner". Journal of Cellular Physiology. 227 (4): 1639–1644. doi:10.1002/jcp.22881. PMC 3206144. PMID 21678416.
^Steidinger TU, Standaert DG, Yacoubian TA (2011). "A neuroprotective role for angiogenin in models of Parkinson's disease". Journal of Neurochemistry. 116 (3): 334–341. doi:10.1111/j.1471-4159.2010.07112.x. PMC 3048053. PMID 21091473.
Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator...
sequences. Cleavage enzymes include Angiogenin, Dicer, RNase Z and RNase P. Especially in the case of Angiogenin, the tRFs have a characteristically unusual...
Lee FS, Shapiro R, Vallee BL (Jan 1989). "Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor". Biochemistry...
angiogenin would need to compete for cell surface actin. If ACTIBIIND forms with the actin first, this would block the formation of actin-angiogenin which...
than adult hemoglobin. Function is not always conserved, however. Human angiogenin diverged from ribonuclease, for example, and while the two paralogs remain...
specific; for example, the ribonuclease inhibitor protein binds to human angiogenin with a sub-femtomolar dissociation constant (<10−15 M) but does not bind...
the tightest known protein–protein complexes is that between the enzyme angiogenin and ribonuclease inhibitor; the dissociation constant for the human proteins...
"Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography". Protein Science. 10 (8): 1669–1676...
polymerase I is AKT-dependent. Certain angiogenic ribonucleases, such as angiogenin (ANG), can translocate and accumulate in the nucleolus. When the concentration...
refer to: Air National Guard, part of the United States National Guard Angiogenin, a protein encoded by the ANG gene Angmering railway station, National...
(September 2013). "Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival"...
vessel structures in whole tumors in animal models. Aerobic exercise Angiogenin The Angiogenesis Foundation Arteriogenesis COL41 Neuroangiogenesis Proteases...
Along with RCSI research fellow Dr. Matt Greenway, Hardiman discovered angiogenin, a novel gene which may be responsible for motor neuron disease. The discovery...
ribonucleases; kidney non-secretory ribonucleases; liver-type ribonucleases; angiogenin, which induces vascularisation of normal and malignant tissues; eosinophil...
factors were identified by other labs that had been inspired by his work: angiogenin and VEGF. With the factors identified, drug discovery could begin. When...
and the liver, displaying a similar distribution pattern to that of angiogenin (ANG). It plays an important role in mRNA cleavage and has marked specificity...
AC, Shapiro R, Acharya KR (Sep 1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at...
PMID 7780165. Moroianu J, Riordan JF (Mar 1994). "Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity"...
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