Bovine pancreatic ribonuclease, also often referred to as bovine pancreatic ribonuclease A or simply RNase A, is a pancreatic ribonuclease enzyme that cleaves single-stranded RNA. Bovine pancreatic ribonuclease is one of the classic model systems of protein science.[1] Two Nobel Prizes in Chemistry have been awarded in recognition of work on bovine pancreatic ribonuclease: in 1972, the Prize was awarded to Christian Anfinsen for his work on protein folding and to Stanford Moore and William Stein for their work on the relationship between the protein's structure and its chemical mechanism;[2] in 1984, the Prize was awarded to Robert Bruce Merrifield for development of chemical synthesis of proteins.[3]
Pancreaticribonuclease family (EC 4.6.1.18, RNase, RNase I, RNase A, pancreatic RNase, ribonuclease I, endoribonuclease I, ribonucleic phosphatase, alkaline...
an RNase that is commonly used in research. RNase A (e.g., bovinepancreaticribonuclease A: PDB: 2AAS) is one of the hardiest enzymes in common laboratory...
purified 1 kg of pure bovinepancreaticribonuclease A and made it freely available to scientists; this gesture helped ribonuclease A become a major target...
"Nonenzymatic Cleavage of Peptide Bonds: The Methionine Residues in BovinePancreaticRibonuclease" (PDF). Journal of Biological Chemistry. 237 (6): 1856–1860...
Ribonucleasepancreatic is an enzyme that in humans is encoded by the RNASE1 gene. This gene encodes a member of the pancreatic-type of secretory ribonucleases...
E. (1970). "A Mechanism of the Irreversible Inactivation of BovinePancreaticRibonuclease by Diethylpyrocarbonate. A General Reaction of Diethylpyrocarbonate...
Bovine seminal RNase (BS-RNase) is a member of the ribonuclease superfamily produced by the bovine seminal vesicles. This enzyme can not be differentiated...
enzyme with an amino acid sequence 33% identical to that of bovinepancreaticribonuclease (RNase A). Ang has the same general catalytic properties as...
Hot Dog Co. purified 1 kg (= one million milligrams) of pure bovinepancreaticribonuclease A and made it available at low cost to scientists around the...
process of oxidative folding is well studied are bovinepancreatic trypsin inhibitor (BPTI) and ribonuclease A (RNaseA). These two proteins have multiple...
Biochemical complementation was first reported in subtilisin-cleaved bovinepancreaticribonuclease, then expanded using β-galactosidase mutants that allowed cells...
protein molecule, specifically bovineribonuclease, in the early 1950s. They determined the entire sequence of ribonuclease by 1960. This sequence combined...
collection and microcrystals for micro electron diffraction. 1967 – Ribonuclease A (PDB file 2RSA) is an RNA-cleaving enzyme stabilized by 4 disulfide...
1990). "Infrared evidence of cyanide binding to iron and copper sites in bovine heart cytochrome c oxidase. Implications regarding oxygen reduction". The...
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