positive regulation of transforming growth factor beta1 production
rostrocaudal neural tube patterning
head morphogenesis
regulation of MAPK cascade
eye pigmentation
angiotensin maturation
positive regulation of Wnt signaling pathway
neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10159
70495
Ensembl
ENSG00000182220
ENSMUSG00000031007
UniProt
O75787
Q9CYN9
RefSeq (mRNA)
NM_005765
NM_027439
RefSeq (protein)
NP_005756
NP_081715
Location (UCSC)
Chr X: 40.58 – 40.61 Mb
Chr X: 12.45 – 12.48 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
^Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
^"Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
pressure. Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)reninreceptor, also known as the reninreceptor and prorenin...
humans is encoded by the ATP6AP2 gene. The reninreceptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen...
angiotensin receptor blockers (ARBs) and aldosterone receptor antagonists. These drugs inhibit the first and rate-limiting step of the renin–angiotensin–aldosterone...
agents that bind to and inhibit the angiotensin II type 1 receptor (AT1) and thus inhibit the renin-angiotensin system and its cascade of effects in causing...
II receptors, (ATR1) and (ATR2), are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin–angiotensin...
precursor for renin, the hormone that activates the renin–angiotensin system, which serves to raise blood pressure. Prorenin is converted into renin by the juxtaglomerular...
rate increase renin secretion from juxtaglomerular cells of the kidney increase ghrelin secretion from the stomach Actions of the β2 receptor include: smooth...
atrial natriuretic hormone secreted by the heart. Aldosterone is part of the renin–angiotensin–aldosterone system. It has a plasma half-life of less than 20...
causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates...
Plasma renin activity (PRA), also known as the renin (active) assay or random plasma renin, is a measure of the activity of the plasma enzyme renin, which...
a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin". Proceedings of the Society...
Angiotensin II receptor blocker Discovery and development of angiotensin receptor blockers Loop diuretic, also used to treat CHF Renin inhibitor Kaplan's...
agents, but receptor selectivity diminishes at higher doses. Beta blockade, especially of the beta-1 receptor at the macula densa, inhibits renin release...
by Novartis) is a renin inhibitor which has been approved by the U.S. FDA for the treatment of hypertension. Aldosterone receptor antagonists, also known...
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin...
see figure 2. Ang II in plasma then binds to AT-receptors. ARBs are blocking the last part of the renin–angiotensin pathway and block the pathway more...
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate...
external or internal. Receptors include thermoreceptors and mechanoreceptors. Control centers include the respiratory center and the renin-angiotensin system...
Anemia may occur, due to inhibition of the renin–angiotensin system. As with other angiotensin receptor blockers, losartan may injure the liver, although...
harbor β1 adrenergic receptors. When stimulated by epinephrine or norepinephrine, these receptors induce the secretion of renin. These cells also respond...
glomeruli. The juxtaglomerular cells secrete renin in response to: Stimulation of the beta-1 adrenergic receptor Decrease in renal perfusion pressure (detected...
of pregnancy as it may harm the baby. Lisinopril works by inhibiting the renin–angiotensin–aldosterone system. Lisinopril was patented in 1978 and approved...
fluid volume or by decreasing cardiac output, with resulting increase in renin release leading to secondary hyperaldosteronism. Secondary hyperaldosteronism...
pressure. Aliskiren is a renin inhibitor, which works to reduce primary hypertension (that with no known cause) by binding to renin and preventing it from...
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