Schematic diagram showing Fc receptor interaction with an antibody-coated microbial pathogen
Identifiers
Symbol
Fc receptor
Membranome
10
In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.
Its name is derived from its binding specificity for a part of an antibody known as the Fc (fragment crystallizable) region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection.[1]
^Anderson R (2003). "Manipulation of cell surface macromolecules by flaviviruses". Advances in Virus Research. 59: 229–74. doi:10.1016/S0065-3527(03)59007-8. ISBN 9780120398591. PMC 7252169. PMID 14696331.
In immunology, an Fcreceptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells...
neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptorFcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded...
cell types, express the Fcreceptor (FcR) molecule (FC-gamma-RIII = CD16), an activating biochemical receptor that binds the Fc portion of IgG class antibodies...
crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fcreceptors and some proteins of...
neonatal Fcreceptor blocker and is a new class of medication. It is an antibody fragment that binds to the neonatal Fcreceptor (FcRn), preventing FcRn from...
abundance in serum (IgG1 being the most abundant). Note: IgG affinity to Fcreceptors on phagocytic cells is specific to individual species from which the...
of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form of the B cell receptor, but they are...
endocytic PRRs, phagocytes furthermore express opsonin receptors such as Fcreceptor and complement receptor 1 (CR1). Should the microbe be coated with opsonising...
expression of Fcreceptors in macrophages, but the evidence supporting this regulation in earlier studies has been questioned. The effect of Fcreceptor expression...
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is a protein that in humans is encoded by the FCER1G gene. The high affinity IgE...
the FcReceptor (FcR) on natural killer cells and other effector cells; the binding of IgG to antigen causes a conformational change that allows FcR to...
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody...
Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates...
Rozanolixizumab is a humanized and chimeric monoclonal antibody; and is a neonatal Fcreceptor blocker. The most common adverse reactions include headache, infections...
inhibitor receptors (KARs and KIRs), complement receptors, Fcreceptors, B cell receptors and T cell receptors. Antigen Lippincott's Illustrated Reviews: Immunology...
Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene. FCGR2A has been shown to interact...
Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fcreceptor which facilitates the...
Fc fragment of IgA receptor (FCAR) is a human gene that codes for the transmembrane receptor FcαRI, also known as CD89 (Cluster of Differentiation 89)...
binding region (Fab) and the Fc region that can be detected by immune system cells via their Fc surface receptors. Fcreceptors are found on many immune system...
identified as Fcreceptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated...
Fucosylation of antibodies has been established to reduce binding to the Fcreceptor of Natural Killer cells and thereby reduce antigen-dependent cellular...
PMID 10972899. Shima, H.; et al. (2010). "Identification of TOSO/FAIM3 as an Fcreceptor for IgM". Int. Immunol. 22 (3): 149–56. doi:10.1093/intimm/dxp121. PMID 20042454...
Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. It is also known as CD16a as it is...
a low affinity Fcreceptor (FcγRIII) which contains N-glycosylation sites; therefore, it is a glycoprotein. Killer Activation Receptors are associated...
Global Information