RASp21proteinactivator 1 or RasGAP (Ras GTPase activatingprotein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal...
Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Rasprotein family members...
inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RASp21proteinactivator2. The two family members have distinct pleckstrin-homology...
located on chromosome 6 (6p21.2) in humans. p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the...
product of KRAS, the K-Rasprotein, was first found as a p21 GTPase. Like other members of the ras subfamily of GTPases, the K-Rasprotein is an early player...
GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming proteinp21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene...
tyrosine kinase activatesRas via phosphorylation of the GAB2 protein, which is dependent on BCR-located phosphorylation of Y177. Ras in particular is...
Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is...
mediate direct binding of the p53 protein, resulting in transcriptional activation of the gene encoding the p21protein. The p53 and RB1 pathways are linked...
prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes...
than that on occasion. The activator E2Fs are E2F1, E2F2 and E2F3 while the repressor E2Fs are E2F4, E2F5 and E2F6. Activator E2Fs along with E2F4 bind...
neurofibromin, a GTPase-activatingprotein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP. NF1 has a...
identical proteins as they differ only the 3′ untranslated region. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to...
TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors...
are encoded by one transcript. Caveolin 2 has been shown to interact with Caveolin 1 and RASp21proteinactivator 1. GRCh38: Ensembl release 89: ENSG00000105971...
autoinhibition in the Rasactivator Son of sevenless". Cell. 119 (3): 393–405. doi:10.1016/j.cell.2004.10.005. PMID 15507210. S2CID 14786628. SOS1+Protein at the U...
LA, Knaus UG (October 1996). "Interaction of the Nck adapter protein with p21-activated kinase (PAK1)". J. Biol. Chem. 271 (42): 25746–9. doi:10.1074/jbc...
the Ink4 proteins and p21, help to prevent improper cyclin-cdk activity. Active cyclin D-cdk complexes phosphorylate retinoblastoma protein (pRb) in the...
downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation...
mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes...
of cell-cell adhesion and migration. Activated Cdc42 activates by causing conformational changes in p21-activated kinases PAK1 and PAK2, which in turn...