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Ras p21 protein activator 2 information


RASA2
Identifiers
AliasesRASA2, GAP1M, RAS p21 protein activator 2
External IDsOMIM: 601589; MGI: 2149960; HomoloGene: 4745; GeneCards: RASA2; OMA:RASA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303245
NM_001303246
NM_006506

NM_053268

RefSeq (protein)

NP_001290174
NP_001290175
NP_006497

NP_444498

Location (UCSC)Chr 3: 141.49 – 141.62 MbChr 9: 96.54 – 96.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. [5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155903 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032413 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.

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Ras p21 protein activator 2

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RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. The protein encoded by this gene is member of the GAP1 family of...

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RAS p21 protein activator 1

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RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal...

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Ras GTPase

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Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members...

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RASA3

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inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology...

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P21

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located on chromosome 6 (6p21.2) in humans. p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the...

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KRAS

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product of KRAS, the K-Ras protein, was first found as a p21 GTPase. Like other members of the ras subfamily of GTPases, the K-Ras protein is an early player...

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Chromosome 3

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Proline and serine rich protein 1 RAB7: RAB7, member RAS oncogene family RASA2: encoding protein Ras p21 protein activator 2 RETNLB: resistin-like beta...

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HRAS

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GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene...

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Philadelphia chromosome

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tyrosine kinase activates Ras via phosphorylation of the GAB2 protein, which is dependent on BCR-located phosphorylation of Y177. Ras in particular is...

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Transforming protein RhoA

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Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is...

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P53

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mediate direct binding of the p53 protein, resulting in transcriptional activation of the gene encoding the p21 protein. The p53 and RB1 pathways are linked...

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Ubiquitin

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prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes...

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Retinoblastoma protein

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than that on occasion. The activator E2Fs are E2F1, E2F2 and E2F3 while the repressor E2Fs are E2F4, E2F5 and E2F6. Activator E2Fs along with E2F4 bind...

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Neurofibromin 1

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neurofibromin, a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP. NF1 has a...

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Neuroblastoma RAS viral oncogene homolog

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identical proteins as they differ only the 3′ untranslated region. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to...

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Parkes Weber syndrome

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2009.03.703. "RASA1 gene RAS p21 protein activator 1". "RASA1 RAS p21 protein activator 1". "RASA1 gene RAS p21 protein activator 1". Mneimneh S, Tabaja...

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Transforming growth factor beta

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TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors...

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Caveolin 2

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are encoded by one transcript. Caveolin 2 has been shown to interact with Caveolin 1 and RAS p21 protein activator 1. GRCh38: Ensembl release 89: ENSG00000105971...

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Son of Sevenless

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autoinhibition in the Ras activator Son of sevenless". Cell. 119 (3): 393–405. doi:10.1016/j.cell.2004.10.005. PMID 15507210. S2CID 14786628. SOS1+Protein at the U...

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NCK1

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LA, Knaus UG (October 1996). "Interaction of the Nck adapter protein with p21-activated kinase (PAK1)". J. Biol. Chem. 271 (42): 25746–9. doi:10.1074/jbc...

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Restriction point

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the Ink4 proteins and p21, help to prevent improper cyclin-cdk activity. Active cyclin D-cdk complexes phosphorylate retinoblastoma protein (pRb) in the...

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Myc

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downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation...

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P14arf

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mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes...

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CDC42

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of cell-cell adhesion and migration. Activated Cdc42 activates by causing conformational changes in p21-activated kinases PAK1 and PAK2, which in turn...

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