RUNX3 information

RUNX3
Identifiers
Aliases	RUNX3, AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3
External IDs	OMIM: 600210 MGI: 102672 HomoloGene: 37914 GeneCards: RUNX3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,965,121 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,905,301 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; tibia; ; spleen; ; monocyte; ; bone marrow cells; ; nipple; ; pylorus; ; parotid gland;
	Top expressed in
	membranous bone; ; human mandible; ; spleen; ; clavicle; ; blood; ; tongue; ; urethra; ; maxilla; ; female urethra; ; male urethra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein binding; ATP binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleolus; intracellular membrane-bounded organelle; nucleoplasm; cytosol; core-binding factor complex;
Biological process	peripheral nervous system neuron development; regulation of transcription, DNA-templated; chondrocyte differentiation; ossification; regulation of transcription by RNA polymerase II; negative regulation of cell cycle; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; protein phosphorylation; negative regulation of epithelial cell proliferation; regulation of cell differentiation; response to transforming growth factor beta; hemopoiesis; negative regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of CD8-positive, alpha-beta T cell differentiation; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	864
	12399
	ENSG00000020633
	ENSMUSG00000070691
	Q13761
	Q3U1Q3
	NM_001031680; NM_004350; NM_001320672
	NM_019732; NM_001369050
	NP_001026850; NP_001307601; NP_004341
	NP_062706; NP_001355979
	Wikidata
View/Edit Human	View/Edit Mouse

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000020633 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070691 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y (Sep 1994). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization". Genomics. 23 (2): 425–32. doi:10.1006/geno.1994.1519. PMID 7835892.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000020633 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070691 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y (Sep 1994). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization". Genomics. 23 (2): 425–32. doi:10.1006/geno.1994.1519. PMID 7835892.

RUNX3 information

and 22 Related for: RUNX3 information

RUNX3

Core binding factor

PKNOX2

Intraepithelial lymphocyte

P53

Zinc finger

List of human transcription factors

Transcription factor

CREB

Estrogen receptor

Hormone receptor

Retinoblastoma protein

NFE2L2

Sigma factor

Heterochromatin protein 1

Progesterone receptor

Vitamin D receptor

Progesterone receptor C

Steroid hormone receptor

Nuclear receptor

STAT3

Corticosteroid receptor