positive regulation of mitotic metaphase/anaphase transition
meiotic chromosome separation
meiotic spindle organization
meiosis I
mitotic sister chromatid segregation
establishment of mitotic spindle localization
apoptotic process
mitotic cell cycle
mitotic cytokinesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9700
105988
Ensembl
ENSG00000135476
ENSMUSG00000058290
UniProt
Q14674
P60330
RefSeq (mRNA)
NM_012291
NM_001014976 NM_001356312
RefSeq (protein)
NP_036423
NP_001014976 NP_001343241
Location (UCSC)
Chr 12: 53.27 – 53.29 Mb
Chr 15: 102.2 – 102.23 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase.[5] In humans, separin is encoded by the ESPL1 gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000135476 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058290 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for...
and is under balanced bipolar tension. Sister chromatids require active separase to hydrolyze the cohesin that bind them together prior to progression to...
is a protein which inhibits a protease known as separase. The destruction of securin unleashes separase which then breaks down cohesin, a protein responsible...
securin and separase are well-conserved proteins (Figure 1). Note that separase cannot function without initially forming the securin-separase complex. This...
break down securin. The latter is a protein whose function is to inhibit separase, which in turn cuts the cohesins, the protein composite responsible for...
can be attributed to the inactivation of topoisomerase II, condensin, or separase. Meiotic nondisjunction has been well studied in Saccharomyces cerevisiae...
mother and daughter centrioles separate dependently on an enzyme called separase. The two centrioles in the centrosome are tied to one another. The mother...
protease partner, separase. Separase bound to securin remains inhibited; however, when inhibition is relieved, activated separase cleaves the cohesin...
are pulled apart from each other. The homologs are cleaved by the enzyme separase to release the cohesin that held the homologous chromosome arms together...
broken down is securin which through its breakdown releases the enzyme separase that cleaves the cohesin rings holding together the sister chromatids thereby...
securin at the end of metaphase releases the active protease called separase. Separase cleaves the cohesion molecules that hold the sister chromatids together...
chromosomal cohesin complex, and its dissolution by the cysteine protease Separase at the metaphase to anaphase transition results in the separation of sister...
cohesin. This includes a binding site for SA1 or SA2, recognition motifs for separase cleavage and a region that is competitively bound by PDS5A, PDS5B or NIPBL...
Rec8 and Rad21 at the centromeres from protein degradation by the enzyme separase. This results in the sister chromatids remaining tethered. Shugoshin also...
as karyopherin β) family, regulatory subunits of condensin and cohesin, separase, PIKKs (phosphatidylinositol 3-kinase-related protein kinases) such as...
remains in complex with SMC proteins until anaphase, where it is degraded by Separase once the spindle assembly checkpoint is bypassed. Unlike the other Kleisin...
degradation of securins, which inhibit separases through binding, at anaphase onset. Released and active separase cleaves cohesin that held sister chromatids...
certificate of election reads: Frank Uhlmann's discovery with Nasmyth of 'separase', the protease that cleaves the cohesive links between sister chromatids...
with PCNT mutations. PCNT has been shown to interact with: calmodulin, separase, CEP215, CHD3/4, protein kinase A, protein kinase C, DISC1, γ-tubulin complex...
sister chromatid cohesion. This cohesion is later broken by the enzyme separase, allowing the chiasmata to be broken and homologous chromosomes to segregate...
degradation of securins, which inhibit separases through binding, at anaphase onset. Released and active separase cleaves cohesin that held sister chromatids...
degraded for cells to exit mitosis. Securin is a protein that inhibits separase, which in turn inhibits cohesin, a protein that holds sister chromatids...
APC/C ubiquitinates securin. The resulting destruction of securing release separase, which hydrolyzes cohesion – the protein that binds sister chromatids together...
‘wait’ signal before activation of separase; at the stage prior to anaphase, securin inhibits the activity of separase and maintains the cohesion complex...
Giménez-Abián JF, Wernic D, Peters JM (Aug 2002). "Regulation of human separase by securin binding and autocleavage". Current Biology. 12 (16): 1368–78...
Global Information
