dentate gyrus of hippocampal formation granule cell
ventromedial nucleus
neural tube
secondary oocyte
superior frontal gyrus
primary visual cortex
lateral hypothalamus
embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
nucleotide binding
GTP binding
calcium-dependent protein binding
protein binding
GTPase activity
protein kinase binding
Cellular component
cytoplasm
filamentous actin
cytosol
cell projection
membrane
growth cone
plasma membrane
neuronal cell body
perinuclear region of cytoplasm
neuron projection
extracellular exosome
cytoskeleton
endomembrane system
cell periphery
lamellipodium
intracellular anatomical structure
Biological process
intracellular signal transduction
neuromuscular process controlling balance
regulation of neuron maturation
synaptic transmission, GABAergic
cerebral cortex GABAergic interneuron development
positive regulation of substrate adhesion-dependent cell spreading
neuromuscular process
cell projection assembly
regulation of cell morphogenesis
homeostasis of number of cells within a tissue
positive regulation of cell adhesion mediated by integrin
neuron projection development
regulation of small GTPase mediated signal transduction
actin cytoskeleton organization
small GTPase mediated signal transduction
cell morphogenesis
actin filament organization
Rho protein signal transduction
cell migration
positive regulation of actin filament polymerization
actin cytoskeleton reorganization
engulfment of apoptotic cell
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5881
170758
Ensembl
ENSG00000169750
ENSMUSG00000018012
UniProt
P60763
P60764
RefSeq (mRNA)
NM_005052 NM_001316307
NM_133223
RefSeq (protein)
NP_001303236 NP_005043
NP_573486
Location (UCSC)
Chr 17: 82.03 – 82.03 Mb
Chr 11: 120.61 – 120.61 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene.[5] It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins.[6][7] Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000169750 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018012 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)".
^Courjal F, Chuchana P, Theillet C, Fort P (September 1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243.
^Haataja L, Groffen J, Heisterkamp N (August 1997). "Characterization of RAC3, a novel member of the Rho family". The Journal of Biological Chemistry. 272 (33): 20384–8. doi:10.1074/jbc.272.33.20384. PMID 9252344.
substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important component of intracellular signalling pathways. Rac3 is a member...
These 20 mammalian members are subdivided in the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, TC10/RhoQ, TCL/RhoJ), the RhoUV family...
HUMAN RAC3 IN COMPLEX WITH GDP 2fju: Activated Rac1 bound to its effector phospholipase C beta 2 2g0n: The Crystal Structure of the Human RAC3 in complex...
1007/s004390050476. PMID 9225980. S2CID 25999127. Li H, Gomes PJ, Chen JD (1997). "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1...
been shown to interact with Rac3, another Rac protein which is expressed in neuronal cells, and this may be because Rac3 is primarily located in the perinuclear...
and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243...
its HAT domain is located in its C-terminal region. ACTR (also known as RAC3, AIB1, and TRAM-1 in humans) shares significant sequence homology with SRC-1...
bind and promote nucleotide exchange on the Rac subfamily isoforms Rac1 and Rac3. This work suggests that Dock7 is a key mediator of the process that specifies...
or neutral membranes. Members of the Rho GTPase family (e.g., Rac1, Rac2, Rac3, and cdc42) have been implicated in their activation by binding to an alternate...
proliferation and differentiation. CIB1 has been shown to interact with RAC3, PSEN2, DNA-PKcs, UBR5 and CD61. GRCh38: Ensembl release 89: ENSG00000185043...
THE HUMAN P21-ACTIVATED KINASE 4 2ov2: The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)...
apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor...
been shown to interact with: CREB-binding protein and EP300, PCAF, PCBD1, RAC3, Src, DCoH Hepatocyte nuclear factors Maturity onset diabetes of the young...
D, Groffen J, Heisterkamp N (Apr 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int J Mol Med. 9 (5):...
Global Information
