Quinapril information

Quinapril
Clinical data
Trade names	Accupril, others
Other names	Quinapril hydrochloride (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a692026
License data	US DailyMed: Quinapril;
Routes of; administration	By mouth
ATC code	C09AA06 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	97%
Elimination half-life	2 hours
Identifiers
	IUPAC name (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;
CAS Number	85441-61-8 ;
PubChem CID	54892;
IUPHAR/BPS	6350;
DrugBank	DB00881 ;
ChemSpider	49565 ;
UNII	RJ84Y44811;
KEGG	D03752 ;
ChEBI	CHEBI:8713 ;
ChEMBL	ChEMBL1592 ;
CompTox Dashboard (EPA)	DTXSID4023547 ;
Chemical and physical data
Formula	C25H30N2O5
Molar mass	438.524 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	120 to 130 °C (248 to 266 °F)
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N2[C@H](C(=O)O)Cc1c(cccc1)C2)C)CCc3ccccc3;
	InChI InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1 ; Key:JSDRRTOADPPCHY-HSQYWUDLSA-N ;
	(verify)

Quinapril, sold under the brand name Accupril^[2] by the Pfizer corporation. It a medication used to treat high blood pressure (hypertension), heart failure, and diabetic kidney disease.^[1]^[3] It is a first line treatment for high blood pressure.^[3] It is taken by mouth.^[1]^[3]

Common side effects include headaches, dizziness, feeling tired, and cough.^[3] Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium.^[3] Use in pregnancy and breastfeeding is not recommended.^[4] It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity.^[3]

Quinapril was patented in 1980 and came into medical use in 1989.^[5] It is available as a generic medication.^[6] In 2020, it was the 253rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[7]^[8]

^ ^a ^b ^c "Accupril- quinapril hydrochloride tablet, film coated Accupril- quinapril tablet, film coated". DailyMed. 26 August 2021. Retrieved 25 March 2022.
^ "ACCUPRIL® Indications and Usage (quinapril HCl) | Pfizer Medical Information - US". www.pfizermedicalinformation.com. Retrieved 25 October 2023.
^ ^a ^b ^c ^d ^e ^f "Quinapril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Quinapril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495.
^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 172. ISBN 9780857113382.
^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
^ "Quinapril - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

[Accupril_FDA_label-1] "Accupril- quinapril hydrochloride tablet, film coated Accupril- quinapril tablet, film coated". DailyMed. 26 August 2021. Retrieved 25 March 2022.

[2] "ACCUPRIL® Indications and Usage (quinapril HCl) | Pfizer Medical Information - US". www.pfizermedicalinformation.com. Retrieved 25 October 2023.

[AHFS2019-3] ^ ^a ^b ^c ^d ^e ^f "Quinapril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-4] "Quinapril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495.

[BNF76-6] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 172. ISBN 9780857113382.

[7] "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.

[8] "Quinapril - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

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