Thus, the two substrates of this enzyme are 5,6,7,8-tetrahydrobiopterin and NADP+, whereas its 3 products are biopterin, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.
and 18 Related for: Pteridine reductase information
In enzymology, a pteridinereductase (EC 1.5.1.33) is an enzyme that catalyzes the chemical reaction 5,6,7,8-tetrahydrobiopterin + 2 NADP+ ⇌ {\displaystyle...
norepinephrine and epinephrine. It is restored to the required cofactor tetrahydrobiopterin by dihydrobiopterin reductase. Pteridine Tetrahydrobiopterin v t e...
substances, including derivatives of pteridines, and belongs to a group of enzymes called aldo-keto reductases. SPR plays an important role in the biosynthesis...
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be...
synthases. Chemically, its structure is that of a (dihydropteridine reductase) reduced pteridine derivative (quinonoid dihydrobiopterin).[citation needed] Tetrahydrobiopterin...
PMID 27320965. S2CID 40014874. Pfleiderer W (February 2008). "Pteridines. Part CXIX. A New Pteridine–Purine Transformation". Helvetica Chimica Acta. 91 (2):...
molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfite oxidase, and nitrate reductase. The only molybdenum-containing enzymes that do not...
Armarego WL, Ohnishi A, Taguchi H (1986). "New pteridine substrates for dihydropteridine reductase and horseradish peroxidase". Biochem. J. 234 (2):...
distinct chemical moieties linked together. A pterin (2-amino-4-hydroxy-pteridine) heterocyclic ring is linked by a methylene bridge to a p-aminobenzoyl...
refractory peripheral T-cell lymphoma (PTCL). Pralatrexate is a dihydrofolate reductase inhibitor. Research on this class of drugs began in the 1950s at SRI International...
fully reduced forms. FAD is also required for the activity of glutathione reductase, an essential enzyme in the formation of the endogenous antioxidant, glutathione...
(eds.). Chemistry and Biology of Pteridines and Folates Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes...
humans, the enzyme is reduced in this process by methionine synthase reductase (MTRR), which consists of flavodoxin-like and ferrodoxin-NADP+ oxidoreductase...
substrate of two enzymes, 6-pyruvoyltetrahydropterin 2'-reductase and sepiapterin reductase. Dyspropterin exists in all living organisms, ranging from...
source, to methyl- THMPT, catalyzed by F420-dependent methylene-THMPT reductase. Methyl- THMPT is the methyl donor to coenzyme M, a conversion mediated...
in this reaction. Then, the NAD(P)H dependent enzyme dihydropteridine reductase (DHPR) converts q-BH2 back to BH4. Each of the four subunits in tyrosine...
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