Sepiapterin reductase information

SPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z6Z, 4HWK, 4J7U, 4J7X, 4XWY, 4Z3K
Identifiers
Aliases	SPR, SDR38C1, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase), sepiapterin reductase
External IDs	OMIM: 182125; MGI: 103078; HomoloGene: 37735; GeneCards: SPR; OMA:SPR - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	72,892,158 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	85,114,748 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; body of pancreas; ; left adrenal gland; ; body of stomach; ; kidney; ; left ventricle; ; islet of Langerhans; ; rectum; ; gastrocnemius muscle;
	Top expressed in
	ankle joint; ; kidney; ; yolk sac; ; left lobe of liver; ; proximal tubule; ; lip; ; mucous cell of stomach; ; interventricular septum; ; crypt of lieberkuhn of small intestine; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sepiapterin reductase activity; aldo-keto reductase (NADP) activity; NADP binding; oxidoreductase activity;
Cellular component	nucleoplasm; extracellular exosome; cytoplasm; cytosol;
Biological process	nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6697
	20751
	ENSG00000116096
	ENSMUSG00000033735
	P35270
	Q64105
	NM_003124
	NM_011467
	NP_003115
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116096 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033735 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ichinose H, Katoh S, Sueoka T, Titani K, Fujita K, Nagatsu T (Oct 1991). "Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis". Biochem Biophys Res Commun. 179 (1): 183–189. doi:10.1016/0006-291X(91)91352-D. PMID 1883349.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP⁺ oxidoreductase)".

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