Protein inhibitor of activated STAT2 information

PIAS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ASQ, 4FO9
Identifiers
Aliases	PIAS2, ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, Protein inhibitor of activated STAT2, protein inhibitor of activated STAT 2
External IDs	OMIM: 603567; MGI: 1096566; HomoloGene: 20979; GeneCards: PIAS2; OMA:PIAS2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	46,920,160 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	77,241,496 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; epithelium of colon; ; secondary oocyte; ; testicle; ; gastrocnemius muscle; ; buccal mucosa cell; ; cerebellar vermis; ; internal globus pallidus;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; ventricular zone; ; Gonadal ridge; ; ganglionic eminence; ; lens; ; tail of embryo; ; neural layer of retina; ; medial ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; zinc ion binding; transcription factor binding; metal ion binding; SUMO ligase activity; ligase activity; protein binding; androgen receptor binding; ubiquitin protein ligase binding; SUMO transferase activity; transferase activity;
Cellular component	PML body; nuclear speck; nuclear body; nucleoplasm; nucleus;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of androgen receptor signaling pathway; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of osteoblast differentiation; positive regulation of transcription by RNA polymerase II; protein sumoylation;
	Sources:Amigo / QuickGO
Orthologs
	9063
	17344
	ENSG00000078043
	ENSMUSG00000025423
	O75928
	Q8C5D8
NM_004671; NM_173206; NM_001324046; NM_001324047; NM_001324048;
	NM_001324049; NM_001324051; NM_001324052; NM_001324053; NM_001324054; NM_001324055; NM_001324057; NM_001324058; NM_001324059; NM_001324060; NM_001354033; NM_001354034; NM_001354035; NM_001354036; NM_001354037; NM_001354038; NM_001354039
	NM_001164167; NM_001164168; NM_001164169; NM_001164170; NM_008602
NP_001310975; NP_001310976; NP_001310977; NP_001310978; NP_001310980;
	NP_001310981; NP_001310982; NP_001310983; NP_001310984; NP_001310986; NP_001310987; NP_001310988; NP_001310989; NP_004662; NP_775298; NP_001340962; NP_001340963; NP_001340964; NP_001340965; NP_001340966; NP_001340967; NP_001340968
	NP_001157639; NP_001157640; NP_001157641; NP_001157642; NP_032628
	Wikidata
View/Edit Human	View/Edit Mouse

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078043 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–31. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
^ Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech Dev. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.
^ "Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078043 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025423 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9724754-5] Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–31. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.

[pmid9256341-6] Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech Dev. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.

[entrez-7] "Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2".

Protein inhibitor of activated STAT2 information

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