SCRIB information

SCRIB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UJU, 1WHA, 1X5Q, 2W4F, 4WYU, 4WYT
Identifiers
Aliases	SCRIB, CRIB1, SCRB1, SCRIB1, Vartul, scribbled planar cell polarity protein, scribble planar cell polarity protein, oSCRIB
External IDs	OMIM: 607733 MGI: 2145950 HomoloGene: 44228 GeneCards: SCRIB
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,815,773 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,941,633 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; skin of abdomen; ; vagina; ; amygdala; ; tibial nerve; ; minor salivary glands; ; pituitary gland; ; anterior pituitary; ; hippocampus proper; ; fundus;
	Top expressed in
	saccule; ; otic placode; ; spermatocyte; ; seminiferous tubule; ; lip; ; internal carotid artery; ; spermatid; ; external carotid artery; ; esophagus; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; guanylate kinase activity; ionotropic glutamate receptor binding; cadherin binding;
Cellular component	postsynaptic membrane; cell projection; membrane; cell-cell junction; adherens junction; plasma membrane; nucleoplasm; myelin sheath abaxonal region; cell junction; cell leading edge; presynapse; extracellular exosome; presynaptic membrane; lamellipodium; Scrib-APC-beta-catenin complex; cytoplasm; cell-cell contact zone; ionotropic glutamate receptor complex; postsynaptic density; basolateral plasma membrane; synapse; glutamatergic synapse; extrinsic component of postsynaptic density membrane;
Biological process	cell differentiation; establishment of apical/basal cell polarity; synaptic vesicle targeting; activation of GTPase activity; astrocyte cell migration; apoptotic process involved in morphogenesis; wound healing; auditory receptor cell morphogenesis; mammary gland duct morphogenesis; auditory receptor cell stereocilium organization; multicellular organism development; neural tube closure; synaptic vesicle endocytosis; protein localization to adherens junction; positive regulation of apoptotic process; positive chemotaxis; morphogenesis of embryonic epithelium; cell population proliferation; viral process; cell migration; cochlear nucleus development; negative regulation of mitotic cell cycle; positive regulation of receptor recycling; chemical synaptic transmission; receptor clustering; establishment or maintenance of epithelial cell apical/basal polarity; GMP metabolic process; GDP metabolic process; receptor localization to synapse; neurotransmitter receptor transport, endosome to postsynaptic membrane; neurotransmitter receptor transport postsynaptic membrane to endosome; suppression by virus of host type I interferon-mediated signaling pathway; suppression by virus of host innate immune response; suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; cell-cell adhesion; protein localization; vesicle-mediated transport in synapse; regulation of postsynaptic neurotransmitter receptor internalization; post-anal tail morphogenesis; inner ear receptor cell stereocilium organization;
	Sources:Amigo / QuickGO
Orthologs
	23513
	105782
	ENSG00000274287; ENSG00000180900
	ENSMUSG00000022568
	Q14160
	Q80U72
	NM_182706; NM_015356
	NM_134089; NM_001310542; NM_001310543
	NP_056171; NP_874365
	NP_001297471; NP_001297472; NP_598850
	Wikidata
View/Edit Human	View/Edit Mouse

SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene.^[5]^[6] It was originally isolated in Drosophila melanogaster in a pathway (also known as the Scribble complex) with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae) as a tumor suppressor.^[7] In humans, SCRIB is found as a membrane protein and is involved in cell migration, cell polarity, and cell proliferation in epithelial cells.^[7]^[8] There is also strong evidence that SCRIB may play a role in cancer progression because of its strong homology to the Drosophila protein.^[7]

^ ^a ^b ^c ENSG00000180900 GRCh38: Ensembl release 89: ENSG00000274287, ENSG00000180900 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022568 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SCRIB scribbled homolog (Drosophila)".
^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ ^a ^b ^c Patrick Humbert; Sarah Russell; Helena Richardson (June 2003). "Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer". BioEssays. 25 (6): 542–53. doi:10.1002/bies.10286. PMID 12766944.
^ L E Dow; J S Kauffman; J Caddy; A S Peterson; S M Jane; S M Russell & P O Humbert (April 2007). "The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge". Oncogene. 26 (16): 2272–82. doi:10.1038/sj.onc.1210016. PMID 17043654.

[refGRCh38Ensembl-1] ENSG00000180900 GRCh38: Ensembl release 89: ENSG00000274287, ENSG00000180900 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022568 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SCRIB scribbled homolog (Drosophila)".

[pmid8590280-6] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.

[PMID_12766944-7] Patrick Humbert; Sarah Russell; Helena Richardson (June 2003). "Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer". BioEssays. 25 (6): 542–53. doi:10.1002/bies.10286. PMID 12766944.

[PMID_17043654-8] L E Dow; J S Kauffman; J Caddy; A S Peterson; S M Jane; S M Russell & P O Humbert (April 2007). "The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge". Oncogene. 26 (16): 2272–82. doi:10.1038/sj.onc.1210016. PMID 17043654.

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