A TEM micrograph showing dengue virus virions (the cluster of dark dots near the center)
Virus classification
(unranked):
Virus
Realm:
Riboviria
Kingdom:
Orthornavirae
Phylum:
Kitrinoviricota
Class:
Flasuviricetes
Order:
Amarillovirales
Family:
Flaviviridae
Genus:
Flavivirus
Species:
Dengue virus
Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus.[1][2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed,[3][4][5] all of which can cause the full spectrum of disease.[1] Nevertheless, scientists' understanding of dengue virus may be simplistic as, rather than distinct antigenic groups, a continuum appears to exist.[6] This same study identified 47 strains of dengue virus.[7] Additionally, coinfection with and lack of rapid tests for Zika virus and chikungunya complicate matters in real-world infections.[8]
Dengue virus has increased dramatically within the last 20 years, becoming one of the worst mosquito-borne human pathogens that tropical countries have to deal with. Current estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical.[9]
^ abRodenhuis-Zybert IA, Wilschut J, Smit JM (August 2010). "Dengue virus life cycle: viral and host factors modulating infectivity". Cellular and Molecular Life Sciences. 67 (16): 2773–86. doi:10.1007/s00018-010-0357-z. PMID 20372965. S2CID 4232236.
^WHO (2009). Dengue Guidelines for Diagnosis, Treatment, Prevention and Control(PDF). World Health Organization. ISBN 978-92-4-154787-1.
^Normile D (October 2013). "Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts". Science. 342 (6157): 415. Bibcode:2013Sci...342..415N. doi:10.1126/science.342.6157.415. PMID 24159024.
^Dwivedi, V. D., Tripathi, I. P., Tripathi, R. C., Bharadwaj, S., & Mishra, S. K. (2017). Genomics, proteomics and evolution of Dengue virus. Briefings in functional genomics.16(4): 217–227, https://doi.org/10.1093/bfgp/elw040
^Taylor-Robinson, Andrew W. (2016-03-03). "A Putative Fifth Serotype of Dengue - Potential Implications for Diagnosis, Therapy and Vaccine Design". International Journal of Clinical & Medical Microbiology. 2016. doi:10.15344/2456-4028/2016/101. ISSN 2456-4028.
^"A new understanding of Dengue virus". ScienceDaily. September 18, 2015. Retrieved May 7, 2016.
^"A Second Time Dengue Infection Can be Life-Threatening Says Research". NDTV. United Kingdom. September 18, 2015. Retrieved 2016-05-07.
^Vogels CB, Rückert C, Cavany SM, Perkins TA, Ebel GD, Grubaugh ND (January 2019). "Arbovirus coinfection and co-transmission: A neglected public health concern?". PLOS Biology. 17 (1): e3000130. doi:10.1371/journal.pbio.3000130. PMC 6358106. PMID 30668574.
^Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI (April 2013). "The global distribution and burden of dengue". Nature. 496 (7446): 504–7. Bibcode:2013Natur.496..504B. doi:10.1038/nature12060. PMC 3651993. PMID 23563266.
Denguevirus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus...
Dengue fever is a mosquito-borne tropical disease caused by denguevirus. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14...
of dengue disease caused by all denguevirus serotypes (1, 2, 3 and 4) in people ages nine through 16 who have laboratory-confirmed previous dengue infection...
genus Flavivirus, which also contains the Zika virus, denguevirus, and yellow fever virus. The virus is primarily transmitted by mosquitoes, mostly species...
RNA viruses in the family Flaviviridae. The genus includes the West Nile virus, denguevirus, tick-borne encephalitis virus, yellow fever virus, Zika...
group Denguevirus Japanese encephalitis virus group Japanese encephalitis virus Murray Valley encephalitis virus St. Louis encephalitis virus West Nile...
where the virus was first isolated in 1947. Zika virus shares a genus with the dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Since...
by RNA viruses include the common cold, influenza, SARS, MERS, COVID-19, Denguevirus, hepatitis C, hepatitis E, West Nile fever, Ebola virus disease...
also be used to diagnose dengue fever. DenguevirusDengue fever "Bio-Rad Launches Test for Early Diagnosis of the DengueVirus | SelectScience". www.selectscience...
In the 2023 dengue outbreak in Jamaica, a significant rise in the number of dengue fever cases was reported in Jamaica. In September 2023 The Ministry...
syndrome, a potential consequence of Zika virus infection. Additionally, as denguevirus is closely related to Zika virus, the vaccine needs to minimize the...
chikungunya, a coinfection of both, or even other similar viruses. The first recognized dengue epidemics occurred almost simultaneously in Asia, Africa...
In the 2005 dengue outbreak in Singapore, a significant rise in the number of dengue fever cases was reported in Singapore, becoming the country's worst...
Corbett worked in Sri Lanka to study the role of human antibodies in denguevirus pathogenesis. While in high school, Corbett realized that she wanted...
Retrieved 4 January 2020. Dengue fever in Indonesia – update 4 11 May 2004 www.who.int, accessed 16 February 2020 "Ebola virus disease" (Press release)...
PMID 33199712. "Yellow Fever Virus - an overview". ScienceDirect Topics. Retrieved 25 April 2022. "Dengue and severe dengue". World Health Organization...
described in relation to influenza virus, SARS-CoV-2, dengue fever, human immunodeficiency virus (HIV) and to several other viruses. This phenomenon was first...
antibodies on their cell membranes specific to the denguevirus. By attaching to these antibodies, dengueviruses from a second infection are better able to infect...
Micronesia. Zika virus (ZIKV) is a vector-borne flavivirus in the same family as yellow fever, dengue, West Nile and Japanese encephalitis viruses. In 2007,...
neighbouring countries in Southeast Asia. A locally uncommon strain of the denguevirus — one that the local populace would be more susceptible to – had begun...
transmission. Yellow fever viruses, Dengue fever viruses, and Zika viruses are of the Flavivirus genera and Chikungunya virus is of the Alphavirus genera...
Global Information
