adenylate cyclase-activating G protein-coupled receptor signaling pathway
inflammatory response
positive regulation of cytosolic calcium ion concentration
positive regulation of gastric mucosal blood circulation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5732
19217
Ensembl
ENSG00000125384
ENSMUSG00000037759
UniProt
P43116
Q62053
RefSeq (mRNA)
NM_000956
NM_008964
RefSeq (protein)
NP_000947
NP_032990
Location (UCSC)
Chr 14: 52.31 – 52.33 Mb
Chr 14: 45.23 – 45.24 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Prostaglandin E2 receptor 2, also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP1, EP3, and EP4, which bind with and mediate cellular responses to PGE2 and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors).[5] EP has been implicated in various physiological and pathological responses.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000125384 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037759 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.
and 29 Related for: Prostaglandin EP2 receptor information
Prostaglandin E2 receptor 2, also known as EP2, is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of...
Prostaglandinreceptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for...
Prostaglandin EP3 receptor (EP3, 53kDa), is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER3; it is one of four identified...
to G coupled protein prostaglandin E2 (PGE2) receptors (EP1, EP2, EP3, and EP4). The activation of these different EP receptors is dependent on the type...
Prostaglandin E2 receptor 4 (EP4) is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans; it is one of four identified...
same prostaglandin to stimulate a reaction in one tissue and inhibit the same reaction in another tissue is determined by the type of receptor to which...
Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of...
Prostaglandin D2 receptor 2 (DP2 or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44. DP2 has also been designated as CD294 (cluster of...
Prostaglandin analogues are a class of drugs that bind to a prostaglandinreceptor. Wider use of prostaglandin analogues is limited by unwanted side effects...
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost is a naturally occurring prostaglandin used in medicine to induce...
Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandinreceptor encoded by the PTGER1 gene. EP1 is one of four identified EP receptors, EP1, EP2, EP3...
The prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), is primarily a receptor for prostaglandin...
Prostaglandin E1 (PGE1) is a naturally occurring prostaglandin and is also used as a medication (alprostadil). In infants with congenital heart defects...
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by...
administered intravenously to horses. A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, although...
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation...
The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. Also known as PTGDR or DP receptors...
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1)...
non-selectively to block the prostaglandin synthesis by inhibition of prostaglandin G/H synthesis 1 and 2. Prostaglandin functions in the body as a messenger...
Prostaglandin H2 (PGH2), or prostaglandin H2 (PGH2), is a type of prostaglandin and a precursor for many other biologically significant molecules. It...
of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize...
enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H2 to thromboxane. People with asthma tend to have increased thromboxane...
selectivity for COX-2 inhibition over COX-1. This reduces the generation of prostaglandins (PGs) from arachidonic acid. The clinical relevance of the drug stems...
and stimulates prostaglandinEP2receptors, prostaglandin EP3 receptor and prostaglandin EP4 receptor but not prostaglandin EP1 receptor and therefore...
ω-6) with elongation and unsaturation. AA is the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine...
characterized by a fast onset of action. It works by blocking the production of prostaglandins (a chemical associated with pain), thereby relieving pain and inflammation...
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