adenylate cyclase-modulating G protein-coupled receptor signaling pathway
ERK1 and ERK2 cascade
response to mechanical stimulus
negative regulation of eosinophil extravasation
regulation of stress fiber assembly
JNK cascade
cellular response to mechanical stimulus
response to lipopolysaccharide
immune response
regulation of ossification
T-helper cell differentiation
bone development
negative regulation of inflammatory response
signal transduction
cellular response to prostaglandin E stimulus
G protein-coupled receptor signaling pathway
inflammatory response
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5734
19219
Ensembl
ENSG00000171522
ENSMUSG00000039942
UniProt
P35408
P32240
RefSeq (mRNA)
NM_000958
NM_001136079 NM_008965
RefSeq (protein)
NP_000949
NP_001129551 NP_032991
Location (UCSC)
Chr 5: 40.68 – 40.69 Mb
Chr 15: 5.24 – 5.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans;[5] it is one of four identified EP receptors, the others being EP1, EP2, and EP3, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP4 has been implicated in various physiological and pathological responses in animal models and humans.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000171522 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039942 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"PTGER3 prostaglandin e receptor 3 [Homo sapiens (Human)] - Gene - NCBI". Archived from the original on 2016-02-26. Retrieved 2017-01-24.
^Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.
and 29 Related for: Prostaglandin EP4 receptor information
Prostaglandin E2 receptor 4 (EP4) is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans; it is one of four identified...
to G coupled protein prostaglandin E2 (PGE2) receptors (EP1, EP2, EP3, and EP4). The activation of these different EP receptors is dependent on the type...
Prostaglandin EP3 receptor (EP3, 53kDa), is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER3; it is one of four identified...
Prostaglandinreceptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for...
Prostaglandin E2 receptor 2, also known as EP2, is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of...
X (September 2016). "Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4receptor in endometrial cancer"...
Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of...
Prostaglandin D2 receptor 2 (DP2 or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44. DP2 has also been designated as CD294 (cluster of...
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost is a naturally occurring prostaglandin used in medicine to induce...
The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. Also known as PTGDR or DP receptors...
Prostaglandin analogues are a class of drugs that bind to a prostaglandinreceptor. Wider use of prostaglandin analogues is limited by unwanted side effects...
the prostaglandinEP4receptor, one out of the four prostaglandin E2 (PGE2) receptor subgroups. The EP4receptor then mediates the prostaglandin-E2-elicited...
prostaglandinEP4receptor, one of four receptors for prostaglandin E2. Activation of EP4 promotes bone remodeling and deposition (see prostaglandin EP4...
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by...
Prostaglandin E1 (PGE1) is a naturally occurring prostaglandin and is also used as a medication (alprostadil). In infants with congenital heart defects...
The prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), is primarily a receptor for prostaglandin...
Prostaglandin G2 is an organic peroxide belonging to the family of prostaglandins. The compound has been isolated as a solid, although it is usually used...
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1)...
administered intravenously to horses. A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, although...
enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H2 to thromboxane. People with asthma tend to have increased thromboxane...
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation...
and stimulates prostaglandin EP2 receptors, prostaglandin EP3 receptor and prostaglandinEP4receptor but not prostaglandin EP1 receptor and therefore...
effect of grapiprant, a prostaglandinEP4receptor antagonist, which uses allosteric inhibition to prevent PGE2 to bind to its receptor as opposed to generally...
of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize...
ω-6) with elongation and unsaturation. AA is the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine...
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