adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of gastric emptying
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5731
19216
Ensembl
ENSG00000160951
ENSMUSG00000019464
UniProt
P34995
P35375
RefSeq (mRNA)
NM_000955
NM_013641
RefSeq (protein)
NP_000946
NP_038669
Location (UCSC)
Chr 19: 14.47 – 14.48 Mb
Chr 8: 84.39 – 84.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. EP1 is one of four identified EP receptors, EP1, EP2, EP3, and EP4 which bind with and mediate cellular responses principally to prostaglandin E2) (PGE2) and also but generally with lesser affinity and responsiveness to certain other prostanoids (see Prostaglandin receptors).[5] Animal model studies have implicated EP1 in various physiological and pathological responses. However, key differences in the distribution of EP1 between these test animals and humans as well as other complicating issues make it difficult to establish the function(s) of this receptor in human health and disease.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000160951 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000019464 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa".
^Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.
and 29 Related for: Prostaglandin EP1 receptor information
Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandinreceptor encoded by the PTGER1 gene. EP1 is one of four identified EP receptors, EP1, EP2,...
Prostaglandin EP3 receptor (EP3, 53kDa), is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER3; it is one of four identified...
Prostaglandinreceptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for...
G-protein-coupled receptors. These receptors are termed DP1-2, EP1-4, FP, IP1-2, and TP, corresponding to the receptor that ligates the corresponding prostaglandin (e...
Prostaglandin E2 receptor 2, also known as EP2, is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of...
to G coupled protein prostaglandin E2 (PGE2) receptors (EP1, EP2, EP3, and EP4). The activation of these different EP receptors is dependent on the type...
Prostaglandin E2 receptor 4 (EP4) is a prostaglandinreceptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans; it is one of four identified...
the prostaglandinreceptors class of receptors and include the following Protein isoforms: Prostaglandin E2 receptor 1 (EP1) - PTGER1 Prostaglandin E2...
Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of...
Prostaglandin D2 receptor 2 (DP2 or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44. DP2 has also been designated as CD294 (cluster of...
Prostaglandin analogues are a class of drugs that bind to a prostaglandinreceptor. Wider use of prostaglandin analogues is limited by unwanted side effects...
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by...
Prostaglandin E1 (PGE1) is a naturally occurring prostaglandin and is also used as a medication (alprostadil). In infants with congenital heart defects...
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost is a naturally occurring prostaglandin used in medicine to induce...
Prostaglandin H2 (PGH2), or prostaglandin H2 (PGH2), is a type of prostaglandin and a precursor for many other biologically significant molecules. It...
Jaxx, 1994 EP1, an EP by Viktoria Modesta, 2010 ProstaglandinEP1receptor, a human gene EP1 procyclin, a trypanosome procyclin protein EP1 (electric locomotive)...
The prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), is primarily a receptor for prostaglandin...
administered intravenously to horses. A single dose has been shown to reduce prostaglandin E2 production and inflammatory exudate for up to 15 hours, although...
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation...
enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H2 to thromboxane. People with asthma tend to have increased thromboxane...
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1)...
of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize...
and stimulates prostaglandin EP2 receptors, prostaglandin EP3 receptor and prostaglandin EP4 receptor but not prostaglandinEP1receptor and therefore...
non-selectively to block the prostaglandin synthesis by inhibition of prostaglandin G/H synthesis 1 and 2. Prostaglandin functions in the body as a messenger...
The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. Also known as PTGDR or DP receptors...
EP-(PGE2) (PGE2 receptor) EP1-(PGE2) (PTGER1) – PTGER1; EP1 is a receptor for prostaglandin E2; relative potencies in binding to and stimulating EP1 are...
selectivity for COX-2 inhibition over COX-1. This reduces the generation of prostaglandins (PGs) from arachidonic acid. The clinical relevance of the drug stems...
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