Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers.[1] For Hodgkin's it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine.[1] It is typically taken by mouth.[1]
Common side effect include low blood cell counts and vomiting.[1] Other side effects include tiredness and depression.[2][3] It is not recommended in people with severe liver or kidney problems.[4] Use in pregnancy is known to harm the baby.[1] Procarbazine is in the alkylating agents family of medication.[1] How it works is not clearly known.[1]
Procarbazine was approved for medical use in the United States in 1969.[1] It is on the World Health Organization's List of Essential Medicines.[5][6] In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds.[4]
^ abcdefgh"Procarbazine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^"Procarbazine Capsules 50mg – Summary of Product Characteristics". UK Electronic Medicines Compendium. 24 November 2014. Archived from the original on 20 December 2016.
^World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 228. hdl:10665/44053. ISBN 9789241547659.
^ abBritish national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 606. ISBN 9780857111562.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers. For Hodgkin's it is often used together with...
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