Plitidepsin
Names
Systematic IUPAC name
(2S )-N -[(1R )-1-({(3S ,6R ,7S ,10R ,11S ,15S ,17S ,20S ,25aS )-10-[(2S )-Butan-2-yl]-11-hydroxy-3-[(4-methoxyphenyl)methyl]-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15H -pyrrolo[2,1-d ] [10,19,1,4,7,14]dioxatetraazacyclotricosin-7-yl}carbamoyl)-3-methylbutyl]-N -methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide
Other names
Aplidine; Dehydrodidemnin B; Aplidin; N -[1-(1,2-Dioxopropyl)-L -prolyl]didemnin A
Identifiers
CAS Number
137219-37-5 Y
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
26001665 Y
DrugBank
KEGG
UNII
Y76ID234HW Y
DTXSID0040418
InChI=1S/C59H91N7O14/c1-15-35(8)50-47(69)30-49(71)80-53(34(6)7)52(72)37(10)54(73)60-41(26-32(2)3)58(77)65-24-16-18-42(65)48(70)31-63(12)44(29-39-20-22-40(79-14)23-21-39)46(68)28-36(9)51(56(75)61-50)62-55(74)45(27-33(4)5)64(13)59(78)43-19-17-25-66(43)57(76)38(11)67/h20-23,32-37,41-45,47,50-51,53,69H,15-19,24-31H2,1-14H3,(H,60,73)(H,61,75)(H,62,74)/t35-,36-,37-,41-,42-,43-,44-,45+,47-,50+,51-,53-/m0/s1
Y Key: RZFJKZZAZSUBCF-VETSTYKFSA-N
Y
O=C([C@@H](NC([C@@H](C)C([C@@H](OC(C[C@H](O)[C@H](NC([C@@H](NC([C@H](N(C([C@H]1N(C(C(C)=O)=O)CCC1)=O)C)CC(C)C)=O)[C@@H](C)OC([C@H](CC2=CC=C(OC)C=C2)N3C)=O)=O)[C@@H](C)CC)=O)C(C)C)=O)=O)CC(C)C)N4[C@H](C3=O)CCC4
Properties
Chemical formula
C 57 H 87 N 7 O 15
Molar mass
1110 .357 g·mol−1
Pharmacology
ATC code
L01XX57 (WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Plitidepsin (also known as dehydrodidemnin B , marketed by PharmaMar, S.A. under the trade name Aplidin ) is a chemical compound extracted from the ascidian Aplidium albicans .[1] It is currently undergoing clinical trial testing. It is a member of the class of compounds known as didemnins.
^ Newman DJ, Cragg GM (August 2004). "Marine natural products and related compounds in clinical and advanced preclinical trials". Journal of Natural Products . 67 (8): 1216–38. doi:10.1021/np040031y. PMID 15332835.
Last Update: 2024-01-12T10:49:31Z
Plitidepsin (also known as dehydrodidemnin B, marketed by PharmaMar, S.A. under the trade name Aplidin) is a chemical compound extracted from the ascidian...
Word Count : 615
Last Update: 2024-06-25T06:54:50Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 3144
Last Update: 2024-02-28T06:07:32Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2940
Last Update: 2024-06-14T11:57:41Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1778
Last Update: 2024-05-10T02:57:14Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1438
Last Update: 2024-01-08T00:17:14Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1554
Last Update: 2024-06-19T03:08:53Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1467
Last Update: 2024-02-13T04:10:10Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2770
Last Update: 2024-06-17T05:23:22Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 6082
Last Update: 2024-04-07T05:48:39Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2389
Last Update: 2024-04-19T01:54:54Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2958
Last Update: 2024-05-16T15:19:40Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2816
Last Update: 2024-06-19T14:30:49Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 3953
Last Update: 2024-01-26T20:17:41Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2176
Last Update: 2024-04-07T05:43:58Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2161
Last Update: 2024-05-17T19:42:10Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1553
Last Update: 2024-06-08T06:35:51Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 3988
Last Update: 2024-01-11T13:38:34Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 4385
Last Update: 2024-06-10T05:58:33Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 869
Last Update: 2024-03-15T07:11:45Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1681
Last Update: 2024-03-31T00:12:28Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1915
Last Update: 2024-06-05T15:39:17Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1783
Last Update: 2024-01-01T05:18:03Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 98
Last Update: 2024-01-13T15:32:32Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1264
Last Update: 2024-03-12T21:54:39Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 2144
Last Update: 2024-06-08T21:10:17Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1472
Last Update: 2024-06-08T17:26:38Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1219
Last Update: 2024-06-10T06:53:27Z
Mitoguazone Mitotane Navitoclax Oblimersen† Omacetaxine mepesuccinate Plitidepsin Retinoids (Alitretinoin Tretinoin#) Selinexor Sitimagene ceradenovec...
Word Count : 1014