Mitomycin C information

Mitomycin C
	Skeletal formula
	Ball-and-stick model of the molecular structure determined by X-ray crystallography
Clinical data
Trade names	Mitosol, Mutamycin, Jelmyto
Other names	UGN-101
AHFS/Drugs.com	Monograph
MedlinePlus	a682415
License data	US DailyMed: Mitomycin;
Pregnancy; category	AU: D; ;
Routes of; administration	Intravenous, topical
Drug class	Antineoplastic agent
ATC code	L01DC03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	8–48 min
Identifiers
	IUPAC name {11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate;
CAS Number	50-07-7;
PubChem CID	5746;
PubChem SID	44286993;
IUPHAR/BPS	7089;
DrugBank	DB00305;
ChemSpider	5544;
UNII	50SG953SK6;
KEGG	C06681;
ChEBI	CHEBI:27504;
ChEMBL	ChEMBL105;
CompTox Dashboard (EPA)	DTXSID2020898 ;
ECHA InfoCard	100.000.008
Chemical and physical data
Formula	C15H18N4O5
Molar mass	334.332 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	360 °C (680 °F)
Solubility in water	8.43 g L−1
	SMILES CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]12;
	InChI InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 ; Key:NWIBSHFKIJFRCO-WUDYKRTCSA-N;

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity.

^ Reiss GJ (2011). "KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccdc.csd.cc12bt29. Archived from the original on 19 November 2021. Retrieved 3 November 2021.
^ "Mitomycin (Mutamycin) Use During Pregnancy". Drugs.com. 19 August 2019. Archived from the original on 22 October 2020. Retrieved 15 April 2020.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ "Mitocin mitomycin 20 mg powder for injection vial (370360)". Therapeutic Goods Administration (TGA). 12 August 2022. Archived from the original on 18 March 2023. Retrieved 29 April 2023.
^ "Mitocin (Echo Therapeutics Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 18 March 2023. Retrieved 29 April 2023.

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