Chemical compound
Phenestrol Other names Fenestrol; NSC-183736; hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate
[4-[4-[4-[2-[4-[Bis(2-chloroethyl)amino]phenyl]acetyl]oxyphenyl]hexan-3-yl]phenyl] 2-[4-[bis(2-chloroethyl)amino]phenyl]acetate
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) DTXSID60941425 Formula C 42 H 48 Cl 4 N 2 O 4 Molar mass 786.66 g·mol−1 3D model (JSmol)
CCC(C1=CC=C(C=C1)OC(=O)CC2=CC=C(C=C2)N(CCCl)CCCl)C(CC)C3=CC=C(C=C3)OC(=O)CC4=CC=C(C=C4)N(CCCl)CCCl
InChI=1S/C42H48Cl4N2O4/c1-3-39(33-9-17-37(18-10-33)51-41(49)29-31-5-13-35(14-6-31)47(25-21-43)26-22-44)40(4-2)34-11-19-38(20-12-34)52-42(50)30-32-7-15-36(16-8-32)48(27-23-45)28-24-46/h5-20,39-40H,3-4,21-30H2,1-2H3
Key:GTWGWCYJKHSRHO-UHFFFAOYSA-N
Not to be confused with Fenestrel.
Phenestrol , or fenestrol , also known as hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate , is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent (i.e., chemotherapy drug) and a chlorphenacyl nitrogen mustard ester of hexestrol which was developed in the early 1960s for the treatment of hormone-dependent tumors but was never marketed.[1] [2] [3] [4]
^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 163–. ISBN 978-1-4757-2085-3 .
^ National Cancer Institute (U.S.), Onkologicheskiĭ nauchnyĭ t͡sentr (Akademii͡a medit͡sinskikh nauk SSSR) (1981). Goldin A (ed.). Experimental evaluation of antitumor drugs in the USA and USSR and clinical correlations . U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute. p. 17.
^ Morozova TM, Merkulova TI, Martynov V, Iaguzhinskaia VP, Shkodinskaia EN (1984). "[Properties of alkylating derivatives of estrogens]". Eksperimental'naia Onkologiia (in Russian). 6 (2): 50–54. PMID 6510335.
^ Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM (1988). "[The antineoplastic activity of testiphenon]". Voprosy Onkologii (in Russian). 34 (11): 1363–1368. PMID 3201773.
Last Update: 2023-12-05T13:55:12Z
Phenestrol , or fenestrol, also known as hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate, is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic...
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Last Update: 2024-05-24T01:32:13Z
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