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Triclosan information


Triclosan
Names
Preferred IUPAC name
5-Chloro-2-(2,4-dichlorophenoxy)phenol
Other names
2,4,4′-Trichloro-2′-hydroxydiphenyl ether
5-Chloro-(2,4-dichlorophenoxy)phenol
Trichloro-2′-hydroxydiphenyl ether
CH-3565
Lexol 300
Irgasan DP 300
Ster-Zac
Identifiers
CAS Number
  • 3380-34-5 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:164200 checkY
ChEMBL
  • ChEMBL849 checkY
ChemSpider
  • 5363 checkY
DrugBank
  • DB08604 checkY
ECHA InfoCard 100.020.167 Edit this at Wikidata
KEGG
  • D06226 checkY
PubChem CID
  • 5564
UNII
  • 4NM5039Y5X checkY
CompTox Dashboard (EPA)
  • DTXSID5032498 Edit this at Wikidata
InChI
  • InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H checkY
    Key: XEFQLINVKFYRCS-UHFFFAOYSA-N checkY
  • InChI=1/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
    Key: XEFQLINVKFYRCS-UHFFFAOYAS
SMILES
  • Clc2cc(Cl)ccc2Oc1ccc(Cl)cc1O
Properties
Chemical formula
C12H7Cl3O2
Molar mass 289.54 g·mol−1
Appearance White solid
Density 1.49 g/cm3
Melting point 55–57 °C (131–135 °F; 328–330 K)
Boiling point 120 °C (248 °F; 393 K)
Pharmacology
ATC code
D08AE04 (WHO) D09AA06 (WHO) (medicated dressing)
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
1
0
Flash point 162.2 °C (324.0 °F; 435.3 K)
Safety data sheet (SDS) MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of action to triclocarban. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remains controversial. Additional research seeks to understand its potential effects on organisms and environmental health.

Triclosan was developed in 1966.[1] A 2006 study recommended showering with 2% triclosan as a regimen in surgical units to rid patients' skin of methicillin-resistant Staphylococcus aureus (MRSA).[2]

  1. ^ Boyce JM, Pittet D, Healthcare Infection Control Practices Advisory Committee, HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force (25 October 2002). "Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America". MMWR. Recommendations and Reports. 51 (RR-16): 1–45, quiz CE1–4. PMID 12418624.
  2. ^ Coia J, Duckworth G, Edwards D, Farrington M, Fry C, Humphreys H, Mallaghan C, Tucker D, Joint Working Party of the British Society of Antimicrobial Chemotherapy, Hospital Infection S, Infection Control Nurses Association (2006). "Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities". Journal of Hospital Infection. 63: S1–44. doi:10.1016/j.jhin.2006.01.001. PMID 16581155.

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Triclosan

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activity compared to other oral disinfectants and anti-plaque agents like triclosan and chlorhexidine gluconate. Mouthrinses containing chlorhexidine was...

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Vicryl

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in rapidly healing tissues such as mucous membrane or impregnated with triclosan ("Vicryl Plus Antibacterial") to provide antimicrobial protection of the...

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whose products contain chiefly benzoyl peroxide, sulfur and resorcinol, triclosan, or salicylic acid as active ingredients. Clearasil has a wide range of...

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halogenated (chlorinated, brominated) phenols, such as hexachlorophene, triclosan, trichlorophenol, tribromophenol, pentachlorophenol, salts and isomers...

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Cetylpyridinium chloride

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development. Phenols such as phenol itself (as introduced by Lister) and triclosan, hexachlorophene, chlorocresol, and chloroxylenol. The latter is used...

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(January 1989). "The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis". Journal of Periodontal Research. 24 (1): 75–80...

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Chloroxylenol

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chloroxylenol has been increasing due to the removal of hexachlorophene and later triclosan and others from world markets. It is currently used for control of bacteria...

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DDT

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can be formulated with other, more persistent antimicrobials such as triclosan that slow bacterial growth or with metal chelant compounds such as EDTA...

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