Phendimetrazine information

Phendimetrazine
Clinical data
Trade names	Bontril
AHFS/Drugs.com	Monograph
Pregnancy; category	C (US);
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	BR: Class B2 (Anorectic drugs); CA: Schedule IV; DE: Anlage II (Authorized trade only, not prescriptible); US: Schedule III;
Pharmacokinetic data
Bioavailability	Peak plasma levels occur within 1 to 3 hours. Absorption is usually complete by 4 to 6 hours
Metabolism	Hepatic
Elimination half-life	19-24 hours
Excretion	Urinary elimination
Identifiers
	IUPAC name 3,4-dimethyl-2-phenylmorpholine;
CAS Number	634-03-7 ;
PubChem CID	12460;
DrugBank	DB01579 ;
ChemSpider	11950 ;
UNII	AB2794W8KV;
KEGG	D08347 ;
ChEMBL	ChEMBL1744 ;
CompTox Dashboard (EPA)	DTXSID1023447 ;
ECHA InfoCard	100.010.186
Chemical and physical data
Formula	C12H17NO
Molar mass	191.274 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O2C(c1ccccc1)C(N(C)CC2)C;
	InChI InChI=1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3 ; Key:MFOCDFTXLCYLKU-UHFFFAOYSA-N ;
	(verify)

Phendimetrazine (Bontril, Adipost, Anorex-SR, Appecon, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex) is a stimulant drug of the morpholine chemical class used as an appetite suppressant.^[2]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Landau D, Jackson J, Gonzalez G (2008). "A case of demand ischemia from phendimetrazine". Cases J. 1 (1): 105. doi:10.1186/1757-1626-1-105. PMC 2531092. PMID 18710555.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[pmid18710555-2] Landau D, Jackson J, Gonzalez G (2008). "A case of demand ischemia from phendimetrazine". Cases J. 1 (1): 105. doi:10.1186/1757-1626-1-105. PMC 2531092. PMID 18710555.

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