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Phenmetrazine information


Phenmetrazine
Clinical data
Routes of
administration
Oral, Intravenous, Vaporized, Insufflated, Suppository
ATC code
  • none
Legal status
Legal status
  • AU: S8 (Controlled drug)
  • BR: Class A3 (Psychoactive drugs)[1]
  • CA: Schedule IV
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class B
  • US: Schedule II
  • UN: Psychotropic Schedule II
Pharmacokinetic data
Elimination half-life8 hours
ExcretionRenal
Identifiers
IUPAC name
  • 3-methyl-2-phenylmorpholine
CAS Number
  • 134-49-6 checkY
PubChem CID
  • 4762
DrugBank
  • DB00830 checkY
ChemSpider
  • 4598 checkY
UNII
  • XA501VL3VR
KEGG
  • C07432 checkY
ChEMBL
  • ChEMBL1201208 ☒N
CompTox Dashboard (EPA)
  • DTXSID5023455 Edit this at Wikidata
ECHA InfoCard100.004.677 Edit this at Wikidata
Chemical and physical data
FormulaC11H15NO
Molar mass177.247 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC1C(C2=CC=CC=C2)OCCN1
InChI
  • InChI=1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3 checkY
  • Key:OOBHFESNSZDWIU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenmetrazine (INN, USAN, BAN) (brand name Preludin, and many others) is a stimulant drug first synthesized in 1952 and originally used as an appetite suppressant, but withdrawn from the market in the 1980s due to widespread abuse. It was initially replaced by its analogue phendimetrazine (under the brand name Prelu-2) which functions as a prodrug to phenmetrazine, but now it is rarely prescribed, due to concerns of abuse and addiction. Chemically, phenmetrazine is a substituted amphetamine containing a morpholine ring.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

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phenylmorpholine derivative, closely related to better known drugs such as phenmetrazine and 3-fluorophenmetrazine. It has been identified as a synthetic impurity...

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an appetite suppressant. Phendimetrazine functions as a prodrug to phenmetrazine; approximately 30 percent of an oral dose is converted into it. Phendimetrazine...

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Substituted phenylmorpholine

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or substituted phenmetrazines alternatively, are chemical derivatives of phenylmorpholine or of the psychostimulant drug phenmetrazine. Most such compounds...

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yield). It is an intermediate in the synthesis of the pharmaceuticals phenmetrazine and propoxyphen. Other drugs made from propiophenone include the following:...

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derivative of phenmetrazine and may function as a prodrug due to its similarity to phendimetrazine. Morazone Phendimetrazine Phenmetrazine Triggle DJ (1996)...

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benzphetamine, and was largely discontinued once newer drugs such as phenmetrazine were introduced. It most likely acts primarily as a dopamine releasing...

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Punding

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describe complex, prolonged, purposeless, and stereotyped behaviour in phenmetrazine and chronic amphetamine users, by Swedish forensic psychiatrist G. Rylander...

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Morpholines: Fenbutrazate Fenmetramide Morazone Morforex Phendimetrazine Phenmetrazine Pseudophenmetrazine Oxazolines: 4-MAR Aminorex Clominorex Cyclazodone...

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Methylphenidate

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August 2021. Retrieved 15 June 2009. Finlator J (28 October 1971). "Phenmetrazine and its salts, and Methylphenidate" (PDF). Isomer Design. Bureau of...

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