Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer.[4] It is administered by intravenous injection.[4] There is also an albumin-bound formulation.[4]
Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea.[4] Other side effects include heart problems, increased risk of infection, and lung inflammation.[4] There are concerns that use during pregnancy may cause birth defects.[5][4] Paclitaxel is in the taxane family of medications.[6] It works by interference with the normal function of microtubules during cell division.[4]
Paclitaxel was isolated in 1971 from the Pacific yew and approved for medical use in 1993.[7][8] It is on the World Health Organization's List of Essential Medicines.[9] It has been made from precursors, and more recently through cell culture.[8]
^"Paclitaxel Use During Pregnancy". Drugs.com. 24 January 2019. Archived from the original on 3 December 2020. Retrieved 19 May 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ abcdefg"Paclitaxel". The American Society of Health-System Pharmacists. Archived from the original on 14 September 2017. Retrieved 2 January 2015.
^Berveiller P, Mir O (2012). "Taxanes during pregnancy: probably safe, but still to be optimized". Oncology. 83 (4): 239–240. doi:10.1159/000341820. PMID 22907122.
^Chang AE, Ganz PA, Hayes DF, Kinsella T, Pass HI, Schiller JH, et al. (2007). Oncology: An Evidence-Based Approach. Springer Science & Business Media. p. 34. ISBN 9780387310565. Archived from the original on 21 December 2016.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 512. ISBN 9783527607495. Archived from the original on 21 December 2016.
^ ab"Taxol® (NSC 125973)". National Cancer Institute. Archived from the original on 5 September 2015. Retrieved 14 February 2016. Wayback machine
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer,...
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an...
Paclitaxel trevatide (development codes NG1005 and GRN1005) is an experimental chemotherapy drug that is under development by Angiochem Inc, a Canadian...
of the drug with nab-paclitaxel on people with advanced TNBC concluded. Atezolizumab, in combination with bevacizumab, paclitaxel, and carboplatin, was...
from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents...
severe adverse effects. Docetaxel and paclitaxel have comparable efficacy metastatic breast cancer but paclitaxel has less severe side effects. Additionally...
mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and...
S. Food and Drug Administration approved protein-bound paclitaxel (also known as nab-paclitaxel, sold as Abraxane) used with gemcitabine. This regimen...
Hyaluronidase (PEGPH20) in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Subjects With Hyaluronan-High...
Alpha PGA is used as a delivery aid for paclitaxel, an anticancer drug, under the generic name of paclitaxel poliglumex. Research is underway for its...
source of paclitaxel. Other yew species contain similar compounds with similar biochemical activity. Docetaxel, an analogue of paclitaxel, is derived...
the results of the RAINBOW trial, that compared ramucirumab plus paclitaxel or paclitaxel alone. In December 2014, the FDA approved ramucirumab in combination...
semisynthesis include the early commercial production of the anti-cancer agent paclitaxel from 10-deacetylbaccatin isolated from the needles of Taxus baccata (European...
PXL may refer to: PXL-2000, camcorder Paclitaxel, drug PCL 6 Enhanced, printer command language This disambiguation page lists articles associated with...
phenylalanine and tryptophan. Paclitaxel, in contrast, is a tubulin polymerization stabilizer and is used as a chemotherapeutic drug. Paclitaxel is based on the terpenoid...
effects. The phase II/III trial BELLE-4 compared buparlisib + paclitaxel with paclitaxel alone in patients with advanced or metastatic HER2-negative breast...
anticancer drug paclitaxel (Taxol). The incorporation of the C10 precursor verbenone, a member of the chiral pool, makes the production of paclitaxel more efficient...
can be used to identify the presence of terpenoids. Selected terpenoids Paclitaxel is a diterpenoid anticancer drug. Terpineols are monoterpenoids. Humulones...
adjuvant therapy may consist of chemotherapy (doxorubicin, trastuzumab, paclitaxel, docetaxel, cyclophosphamide, fluorouracil, and methotrexate) and radiotherapy...
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