Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer.[6] This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer.[7] It may be used by itself or along with other chemotherapy medication.[6] It is given by slow injection into a vein.[6]
Common side effects include hair loss, cytopenia (low blood cell counts), numbness, shortness of breath, nausea, vomiting, and muscle pains.[6] Other severe side effects include allergic reactions and future cancers.[6] Docetaxel induced pneumotoxicity is also a well recognized adverse effect which has to be identified timely and treated after withholding the drug.[8] Side effects are more common in people with liver problems.[6] Use during pregnancy may harm the baby.[6] Docetaxel is in the taxane family of medications.[9] It works by disrupting the normal function of microtubules and thereby stopping cell division.[6]
Docetaxel was patented in 1986 and approved for medical use in 1995.[10] It is on the World Health Organization's List of Essential Medicines.[11] Docetaxel is available as a generic medication.[6]
^"Docetaxel Use During Pregnancy". Drugs.com. 4 June 2020. Retrieved 29 October 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^"Taxotere- docetaxel injection, solution, concentrate". DailyMed. 26 December 2019. Retrieved 28 October 2020.
^"Taxotere EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 28 October 2020.
^ abcdefghi"Docetaxel". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^"FDA Approval for Docetaxel". National Cancer Institute. 2006-10-05. Archived from the original on 21 December 2016. Retrieved 21 December 2016.
^Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E (July 2021). "Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature". Respirology Case Reports. 9 (7): e00802. doi:10.1002/rcr2.802. PMC 8200505. PMID 34136263.
^British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 622. ISBN 9780857111562.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 512. ISBN 9783527607495. Archived from the original on 2016-12-21.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This...
fluorouracil Cyclophosphamide, methotrexate, and fluorouracil. Docetaxel and cyclophosphamide. Docetaxel, doxorubicin, and cyclophosphamide Cyclophosphamide, epirubicin...
phase II trial of adding ramucirumab to docetaxel improved progression-free survival (PFS) compared with docetaxel alone in locally advanced or metastatic...
genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA...
compared with 13.2% response rate for docetaxel. Overall survival was not different between sotorasib and docetaxel. At a meeting of FDA Oncologic Drugs...
treatments. Scalp cooling has specifically been used to prevent alopecia in docetaxel chemotherapy, although it has been found prophylactic in other regimens...
Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used...
and colorectal cancer. For breast cancer it is often used together with docetaxel. It is taken by mouth. Common side effects include abdominal pain, vomiting...
treated with continued hormone therapy alongside the chemotherapy drug docetaxel. Some tumors metastasize (spread) to other areas of the body, particularly...
inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and griseofulvin...
e-solutions an international software development and consulting company Docetaxel, an anti-cancer drug Textron, a manufacturing corporation TTX (disambiguation)...
(with docetaxel) published Aug 2013. In July 2014 published results of a phase 2 trial (for NSCLC) concluded : "The addition of PX-866 to docetaxel did...
snake neurotoxin .dtx, source files of Documented LaTeX for DocStrip Docetaxel, a chemotherapy medication DTX (Digital Talent Experience), a team composed...
available for dose optimization of methotrexate, 5-FU, paclitaxel, and docetaxel. The serum albumin level immediately prior to chemotherapy administration...
August 2021. Retrieved 10 June 2014. "AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients". ClinicalTrials...
treatment of metastatic castration-resistant prostate cancer following docetaxel-based treatment. Taxanes enhance microtubule stabilization and inhibit...
disease progression despite treatment. It is also used in combination with docetaxel as a second-line treatment for adult patients with locally advanced, metastatic...
include: doxorubicin/ifosfamide and doxorubicin combination/gemcitabine and docetaxel/trabectedin; pazopanib is the targeted therapy used in metastatic leiomyosarcoma...
currently receiving chemotherapy, is either resistant or intolerant of docetaxel, has a WHO performance status of <2, and his disease has not since become...
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