Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone.[4] It may be used together with other medications to treat pneumonia, and endocarditis.[4] It may also be used prior to surgery to prevent Staphylococcus infections.[4] It is not effective against methicillin-resistant Staphylococcus aureus (MRSA).[5] It is taken by mouth or given by injection into a vein or muscle.[4]
Common side effects include an upset stomach.[4] Other side effects may include muscle or joint pains, shortness of breath, and liver problems.[4][6] It appears to be safe during pregnancy and breastfeeding.[4] It should not be used in those who are allergic to penicillin.[4] It is a narrow-spectrum beta-lactam antibiotic of the penicillin class.[6] It is similar in effect to cloxacillin and dicloxacillin, being active against penicillinase forming bacteria.[7]
Flucloxacillin was patented in 1961.[8] It is not commonly used in the United States or Canada as of 2011.[9]
^"Flucloxacillin". Drugs.com. Retrieved 11 December 2020.
^List of nationally authorised medicinal products. European Medicines Agency. November 2020
^ abHitchings A, Lonsdale D, Burrage D, Baker E (2015). The Top 100 Drugs e-book: Clinical Pharmacology and Practical Prescribing. Churchill Livingstone; Elsevier. p. 181. ISBN 978-0-7020-5516-4.
^ abcdefgh"5.2 Bacterial Infection". British National Formulary (BNF) (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 582–587. ISBN 978-0-85711-369-6.
^"Methicillin-resistant Staphylococcus aureus (MRSA)" (PDF). NHS. 2005. p. 3. Archived from the original (PDF) on 12 December 2020. Retrieved 11 December 2020.
^ abWu AH, Yeo KT (2011). Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory. Springer Science & Business Media. ISBN 978-1-60761-283-4.
^Weller RB, Hunter HJ, Mann MW (2014). Clinical Dermatology. John Wiley & Sons. p. 411. ISBN 978-1-118-85097-8.
^Alapi EM, Fischer J (2006). "Part III. Table of Selected Analogue Classes". In Fischer J, Ganellin CR (eds.). Analogue-based Drug Discovery. Wiley-VCH. p. 491. ISBN 978-3-527-31257-3.
^Devereaux BM, Crawford DH, Purcell P, Powell LW, Roeser HP (1995). "Flucloxacillin associated cholestatic hepatitis. An Australian and Swedish epidemic?". European Journal of Clinical Pharmacology. 49 (1–2): 81–85. doi:10.1007/BF00192363. PMID 8751026. S2CID 1259750.
Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic...
similar in pharmacokinetics, antibacterial activity, and indications to flucloxacillin, and the two agents are considered interchangeable. It is believed to...
penicillinase-resistant penicillins (such as dicloxacillin in the US or flucloxacillin in UK). Fungal folliculitis may require an oral antifungal such as fluconazole...
names, including Cloxapen, Cloxacap, Tegopen and Orbenin. Dicloxacillin Flucloxacillin Nafcillin Oxacillin World Health Organization (2009). Stuart MC, Kouimtzi...
More severe cases require oral antibiotics, such as dicloxacillin, flucloxacillin, or erythromycin. Alternatively, amoxicillin combined with clavulanate...
Beta-lactamase resistant penicillins) cloxacillin, dicloxacillin and flucloxacillin are preferred for oral administration due to better bioavailability...
penicillinase-resistant β-lactam antibiotic (for example, oxacillin or flucloxacillin, both of which have the same mechanism of action as penicillin) or vancomycin...
(by mouth or by injection) Dicloxacillin (by mouth or by injection) Flucloxacillin (by mouth or by injection) Methicillin (injection only) Nafcillin (injection...
orciprenaline, metoclopramide, ranitidine, metoprolol, enoxaparin, flucloxacillin, insulin, and irrigation of both eyes with saline. The treatment after...
oxacillin (used for clinical antimicrobial susceptibility testing), flucloxacillin and dicloxacillin, but the term methicillin-resistant Staphylococcus...
bacteria is a common cause and an anti-staphylococcus antibiotic such as flucloxacillin or dicloxacillin is used. The Infectious Diseases Society of America...
JT, Meurs CJ, Renz J, Groeneveld PH (1 August 1997). "Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus...
beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Leflunomide is an isoxazole-derivative drug. Examples of AAS containing...
cefuroxime and erythromycin in severe cases. Staphylococcus aureus — flucloxacillin (to counteract the organism's β-lactamase). Haemophilus influenzae —...
reasons for this are historical.[citation needed] Cloxacillin (Canada) Flucloxacillin (UK and Australia) Dicloxacillin (US) Methicillin (Withdrawn; was once...
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