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PR toxin information


PR toxin
Names
IUPAC name
(11S)-8,12-Dioxo-1β,2β:7,11-diepoxy-7α-eremophil-9-en-3β-yl acetate
Systematic IUPAC name
(1aR,2R,2′R,3R,3′S,3aR,7bS)-3′-Formyl-3,3′,3a-trimethyl-6-oxo-1a,2,3a,4,6,7b-hexahydro-3H-spiro[naphtho[1,2-b]oxirene-5,2′-oxiran]-2-yl acetate
Identifiers
CAS Number
  • 56299-00-4
3D model (JSmol)
  • Interactive image
3DMet
  • B01991
ChEBI
  • CHEBI:7883
ChEMBL
  • ChEMBL4176158
ChemSpider
  • 389737
KEGG
  • C06079
PubChem CID
  • 440907
UNII
  • F9W0X88AFM
CompTox Dashboard (EPA)
  • DTXSID40971740 Edit this at Wikidata
InChI
  • InChI=1S/C17H20O6/c1-8-12(21-9(2)19)14-13(22-14)10-5-11(20)17(6-15(8,10)3)16(4,7-18)23-17/h5,7-8,12-14H,6H2,1-4H3/t8-,12+,13-,14+,15+,16+,17-/m0/s1
    Key: GSPFUBNBRPVALJ-VIEAGMIOSA-N
SMILES
  • C[C@H]1[C@H]([C@@H]2[C@@H](O2)C3=CC(=O)[C@@]4(C[C@]13C)[C@@](O4)(C)C=O)OC(=O)C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Penicillin Roquefort toxin (PR toxin) is a mycotoxin produced by the fungus Penicillium roqueforti. In 1973, PR toxin was first partially characterized by isolating moldy corn on which the fungi had grown.[1] Although its lethal dose was determined shortly after the isolation of the chemical, details of its toxic effects were not fully clarified until 1982 in a study with mice, rats, anesthetized cats and preparations of isolated rat auricles.[2]

  1. ^ Wei, R.D.; et al. (1973-01-25). "Isolation and Partial Characterization of a Mycotoxin from Penicillium roqueforti". American Society for Microbiology. 25 (1): 111–114. doi:10.1128/am.25.1.111-114.1973. PMC 380745. PMID 4687064.
  2. ^ Chen, F.C.; et al. (1982). "Acute toxicity of PR toxin, a mycotoxin from Penicillium roqueforti'". Toxicon. 20 (2): 433–441. doi:10.1016/0041-0101(82)90006-x. PMID 7080052.

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PR toxin

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roqueforti, and is likely a precursor to the toxin known as PR toxin, made in large amounts by the fungus. PR-toxin has been implicated in incidents of mycotoxicoses...

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Aristolochene is a precursor to PR toxin, a toxic chemical made in large amounts by Penicillium roqueforti. PR toxin has been implicated in incidents...

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