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Bordetella pertussis information



Bordetella pertussis
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
Species:
B. pertussis
Binomial name
Bordetella pertussis
(Bergey et al. 1923) Moreno-López 1952

Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin, adenylate cyclase toxin, filamentous hæmagglutinin, pertactin, fimbria, and tracheal cytotoxin.

The bacteria are spread by airborne droplets and the disease's incubation period is 7–10 days on average (range 6–20 days).[1][2] Humans are the only known reservoir for B. pertussis.[3] The complete B. pertussis genome of 4,086,186 base pairs was published in 2003.[4] Compared to its closest relative B. bronchiseptica, the genome size is greatly reduced. This is mainly due to the adaptation to one host species (human) and the loss of capability of survival outside a host body.[5]

Like B. bronchiseptica, B. pertussis can express a flagellum-like structure, even though it has been historically categorized as a nonmotile bacterium.[6]

  1. ^ Heymann DL, ed. (2008). Pertussis; in Control of Communicable Diseases Manual (19th ed.). Washington DC: American Public Health Association. p. 457. ISBN 978-0-87553-189-2.
  2. ^ Organisation mondiale de la santé, World Health Organization (1998). Relevé épidémiologique hebdomadaire (Online) = Weekly epidemiological record. Organisation mondiale de la sante. OCLC 301147153.
  3. ^ Havers FP, Moro PL, Hariri S, Skoff T (2015). "Pertussis". In Atkinson W, Wolfe S, Hamborsky J (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases: The Pink Book (13th ed.). Centers for Disease Control and Prevention, Public Health Foundation.
  4. ^ Parkhill J, Sebaihia M, Preston A, Murphy LD, Thomson N, Harris DE, et al. (September 2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica". Nature Genetics. 35 (1): 32–40. doi:10.1038/ng1227. PMID 12910271.
  5. ^ Locht C (2007). Bordetella: molecular microbiology. Wymondham: Horizon Bioscience. ISBN 978-1-904933-31-1. OCLC 159579443.
  6. ^ Hoffman CL, Gonyar LA, Zacca F, Sisti F, Fernandez J, Wong T, et al. (May 2019). "Bordetella pertussis Can Be Motile and Express Flagellum-Like Structures". mBio. 10 (3): e00787–19. doi:10.1128/mBio.00787-19. PMC 6520453. PMID 31088927.

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Bordetella pertussis

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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of...

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Bordetella

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Pertussis toxin

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Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in...

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Whooping cough

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vaccinated, but symptoms are typically milder. Pertussis is caused by the bacterium Bordetella pertussis, which is spread easily through the coughs and...

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DPT vaccine

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toxoids, and either killed whole cells of the bacterium that causes pertussis or pertussis antigens. The term toxoid refers to vaccines which use an inactivated...

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Pertussis vaccine

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Pertussis vaccine is a vaccine that protects against whooping cough (pertussis). There are two main types: whole-cell vaccines and acellular vaccines....

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Bordetella bronchiseptica

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rarely infects humans. Closely related to B. pertussis—the obligate human pathogen that causes pertussis (whooping cough); B. bronchiseptica can persist...

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Pertactin

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(PRN) is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that causes pertussis. Specifically, it is an outer membrane protein...

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Bordetella holmesii

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conjunction with Bordetella pertussis infections (whooping cough), although not always. Weyant, Robbin S.; et al. (1995). "Bordetella holmesii sp. nov...

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Bronchitis

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caused by a bacterial infection such as Mycoplasma pneumoniae or Bordetella pertussis. Risk factors include exposure to tobacco smoke, dust, and other...

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RTX toxin

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of the adenylate cyclase toxin (ACT or CyaA; TC# 1.C.11.1.4) of Bordetella pertussis forms a small cation-selective channel, disrupting the permeability...

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Adenylate cyclase toxin

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whooping cough, Bordetella pertussis. Bordetella bronchiseptica and Bordetella parapertussis, also able to cause pertussis-like symptoms, also produce...

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Tracheal cytotoxin

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Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis, Vibrio fischeri (as a symbiosis chemical), and Neisseria gonorrhoeae...

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Coccobacillus

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Acinetobacter strains may grow on solid media as coccobacilli. Bordetella pertussis is a Gram-negative coccobacillus responsible for causing whooping...

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Pathogenic bacteria

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Bordet-Gengou and modified Regan-Lowe media for the isolation of Bordetella pertussis and Bordetella parapertussis". J. Clin. Microbiol. 26 (12): 2661–3. doi:10...

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Extracellular adenylate cyclase

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cyclase produced by Bordetella pertussis. Kessin RH, Franke J (April 1986). "Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements...

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Toxoid

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ISBN 9781904455745. OCLC 630453151.{{cite book}}: CS1 maint: others (link) "Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated)". go.drugbank...

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CyaA

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Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host’s respiratory...

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Bordetella hinzii

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Bordetella hinzii is a Gram-negative, oxidase+ and catalase-positive, short rod-shaped bacterium from the genus Bordetella isolated from a patient who...

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Microbial toxin

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occurs with inhalation. Bordetella pertussis targets cilia of the upper respiratory tract which are damaged by the pertussis toxin, an ADP-ribosyltransferase...

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List of clinically important bacteria

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Bartonella Bartonella henselae Bartonella quintana Bordetella Bordetella bronchiseptica Bordetella pertussis Borrelia burgdorferi Brucella Brucella abortus...

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Adenylyl cyclase

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toxins secreted by pathogenic bacteria such as Bacillus anthracis, Bordetella pertussis, Pseudomonas aeruginosa, and Vibrio vulnificus during infections...

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Acute bronchitis

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levels of air pollution or bacteria such as Mycoplasma pneumoniae or Bordetella pertussis. Diagnosis is typically based on a person's signs and symptom. The...

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Helicobacter pylori

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Burkholderia pseudomallei Melioidosis Burkholderia mallei Glanders Burkholderia cepacia complex Bordetella pertussis/Bordetella parapertussis Pertussis...

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Bordetella trematum

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phenotypically identical. Bordetella trematum and B. holmesii are the only species that do not colonize the respiratory tract. B. pertussis and B. parapertussis...

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Filamentous haemagglutinin adhesin

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notable bacterium that produces filamentous haemagglutinin adhesin is Bordetella pertussis, which uses this protein as a virulence factor. Adhesin (disambiguation)...

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Bacterial pneumonia

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(J15.0), Escherichia coli (J15.5), Pseudomonas aeruginosa (J15.1), Bordetella pertussis, and Moraxella catarrhalis are the most common. These bacteria often...

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