negative regulation of transcription by RNA polymerase II
circadian regulation of gene expression
transcription, DNA-templated
fatty acid metabolic process
regulation of cell cycle
negative regulation of protein ubiquitination
circadian regulation of translation
response to ischemia
regulation of vasoconstriction
glycogen biosynthetic process
negative regulation of transcription regulatory region DNA binding
regulation of circadian rhythm
circadian rhythm
white fat cell differentiation
regulation of glutamate uptake involved in transmission of nerve impulse
lactate biosynthetic process
negative regulation of transcription, DNA-templated
regulation of neurogenesis
positive regulation of nucleic acid-templated transcription
response to light stimulus
entrainment of circadian clock by photoperiod
positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8864
18627
Ensembl
ENSG00000132326
ENSMUSG00000055866
UniProt
O15055
O54943
RefSeq (mRNA)
NM_003894 NM_022817
NM_011066
RefSeq (protein)
NP_073728
NP_035196
Location (UCSC)
Chr 2: 238.24 – 238.29 Mb
Chr 1: 91.34 – 91.39 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000132326 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055866 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM (Dec 1997). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron. 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. S2CID 10059149.
^Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ (Jan 2007). "Modeling of a human circadian mutation yields insights into clock regulation by PER2". Cell. 128 (1): 59–70. doi:10.1016/j.cell.2006.11.043. PMC 1828903. PMID 17218255.
PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms. The per gene was first discovered using...
production of hPER2 protein. In a wildtype individual, Per2 mRNA is transcribed and translated to form a PER2 protein. Large concentrations of PER2 protein inhibits...
two-stroke but the engine was now the updated Hi-Per2 unit. The Zip SP had the water-cooled Hi-Per2 Pro engine and single sided front suspension. In the...
circadian protein homolog 3 protein in humans. PER3 is a paralog to the PER1 and PER2 genes. It is a circadian gene associated with delayed sleep phase syndrome...
hormone), and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM (cAMP response...
Per2 protein accumulates and is phosphorylated by CK1E. Per2 subsequently inhibits the transcription factors Clock and BMAL1 in order to reduce Per2 protein...
within the SCN. Knowledge of the gene expression of Clock (Clk) and Period2 (Per2), two of the many genes responsible for regulating circadian rhythm within...
cells by the cyclical activity of core clock genes and proteins such as per2/PER2. Gamma-aminobutyric acid and several peptide factors, including cytokines...
24 PER MAG MNZ 15 MIS 8 VAR Ret IMO MUG BIN EST 3 13th 27 2002 RC Motorsport VAL 1 PER1 1 PER2 6 SPA 1 MAG 6 MNZ 3 VAR Ret IMO 1 MIS Ret MUG 3 2nd 188...
shown in a study by Shigeyoshi et al. 2002. In this study, mouse mPer1 and mPer2 genes were driven by Drosophila timeless promoter in Drosophila melanogaster...
suprachiasmatic nucleus (SCN), the centre for circadian rhythm control in humans. PER2 is a well-known regulator of circadian rhythms and contains a variant recently...
Some of his work includes identifying phosphorylation regions on mPER2 (mammalian PER2) and their implications for familial advanced sleep phase syndrome...
phase syndrome is caused by a single amino acid change, S662➔G, in the human PER2 protein. To be called circadian, a biological rhythm must meet these three...
Texas Southwestern Medical Center, used multiple Raleigh plots to illustrate PER2::LUC expression in her 2013 paper "Methamphetamine and Dopamine Receptor...
models (since 1998) had optional air-cooling and rear disc brakes (the Hi-Per2 engine). The mc3 saw not only further visual improvements, but also a rev...
ISBN 9781451113419. Ikegami, K; Iigo, M; Yoshimura, T (2013). "Circadian clock gene Per2 is not necessary for the photoperiodic response in mice". PLOS ONE. 8 (3):...
research group at Hokkaido University found daily rhythms of PER2 protein in nasal mucus. PER2 peaks at the beginning of the dark period of each circadian...
how entrainment occurs. Genes also involved with entrainment are PER1 and PER2. Some important structures directly impacted by the light-sleep relationship...
Engine Two-stroke water cooled Piaggio Hi-PER2 PRO 49.4 cc (50SP) Four-stroke water cooled 124.0 cc (125), 198.0 cc (200) Transmission Belt-driven continuously...
phosphorylation of CREB and other transcriptional factors. The mPer1 and mPer2 promoters have CRE domains and thus provides the mechanism for VIP to regulate...
150 cm3, all homologated Euro 2: the 50 was available both with two-stroke Hi-PER2 air-cooled and equipped with a two-stage catalytic converter with Secondary...
following activation of the Cry1 promoter. Whereas rhythms in Per2 promoter activation and Per2 mRNA levels have almost the same phase, Cry1 mRNA production...
PER1 v PER2 Week 3 10–13 March 1998 ECU2 v COL1, ECU1 v COL1 MEX2 v BRA2, MEX1 v BRA2 PAR2 v CHI2, PAR1 v CHI2 BOL2 v URU2, BOL1 v URU2 ARG2 v PER2, PER1...
mode of inheritance. It is associated with a missense mutation in human PER2 that replaces serine for glycine at position 662 (S662G). Irregular sleep–wake...
transcription of target genes such as the core clock genes 'period' genes (PER1, PER2, and PER3) and two cryptochrome genes (CRY1 and CRY2). Negative feedback...
Global Information
