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PER3 information


PER3
Identifiers
AliasesPER3, GIG13, FASPS3, period circadian clock 3, period circadian regulator 3
External IDsOMIM: 603427; MGI: 1277134; HomoloGene: 7886; GeneCards: PER3; OMA:PER3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011067
NM_001289877
NM_001289878

RefSeq (protein)

NP_001276806
NP_001276807
NP_035197

Location (UCSC)Chr 1: 7.78 – 7.85 MbChr 4: 151 – 151.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The PER3 gene encodes the period circadian protein homolog 3 protein in humans.[5] PER3 is a paralog to the PER1 and PER2 genes. It is a circadian gene associated with delayed sleep phase syndrome in humans.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049246 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028957 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM (December 1997). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron. 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. S2CID 10059149.
  6. ^ Cite error: The named reference Archer, 2003 was invoked but never defined (see the help page).

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PER3

Last Update:

the PER3 gene in other species: PER3 (P. troglodytes) PER3 (M. mulatta) PER3 (C. lupus) PER3 (H. sapiens) PER3 (B. taurus) Per3 (M. musculus) Per3 (R....

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Delayed sleep phase disorder

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growing body of evidence suggests that the problem is associated with the hPer3 (human period 3) gene and CRY1 gene. For people who may have a circadian...

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Circadian rhythm

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Light effects on circadian rhythm Light in school buildings PER1, PER2, and PER3: the period family genes Photosensitive ganglion cell: part of the eye which...

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Hitoshi Okamura

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mammalian period gene PER1 in mice and humans. They also discovered PER2, PER3, and the mammalian homolog of the Drosophila gene timeless. They found that...

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Suprachiasmatic nucleus

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known homologs for the period gene in Drosophila, namely per1, per2, and per3. As per and cry are transcribed and translated into PER and CRY, the proteins...

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Familial sleep traits

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have been identified as the causes of these sleep traits, including PER2, PER3, CRY2, CRY1. Other Mendelian genes that are not known to play a core role...

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Circadian clock

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target genes such as the core clock genes 'period' genes (PER1, PER2, and PER3) and two cryptochrome genes (CRY1 and CRY2). Negative feedback is achieved...

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List of Amazon locations

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Geelong (DS) (opening 2023) Western Australia Perth Airport (FC) (2019) (PER3) Jandakot Airport (FC) (2023) (PER4) High Wycombe (FC) (VANC) Kewdale (DS)...

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PAS domain

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via their PAS domains. That activator complex regulates Per1, Per2, and Per3 which all have PAS domains that are used to bind to cryptochromes 1 and 2...

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PER2

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double-knockout animals are placed in constant conditions. A third PER gene, mPer3, does not have a critical role in the maintenance of the core clock feedback...

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Epigenetics in forensic science

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died from a variety of causes, there was partial methylation at the PER2, PER3, CRY1, and TIM promoters which are important genes in controlling the circadian...

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Functional element SNPs database

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rs2304669; PER3: rs2640908, rs172933, rs2859390, rs228669. When the dominant genetic model was tested, their data showed that only SNP rs2640908 in PER3 gene...

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Casein kinase 1

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periodically binds to and phosphorylates the PER proteins (PER1, PER2, and PER3), which form heterodimers with each other and interact with CRY1 and CRY2...

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Hajime Tei

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and Hitoshi Okamura to discover the mammalian period genes Per1, Per2, and Per3. They also discovered the mammalian homolog of the Drosophila gene Timeless...

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Oscillating gene

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dawn and is followed by increases in the levels of mPer3 and then by mPer2. mPer1 peaks at CT 4-6, mPer3 at CT 4 and 8 and mPer2 at CT 8. mPer1 is necessary...

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Casein kinase 1 isoform epsilon

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lengthening effects. Furthermore, in humans, the P415A and H417R mutations in PER3 have been shown to destabilize the protein. These mutations have been shown...

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Ueli Schibler

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Weaver, David (May 2001). "Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock". Neuron. 30 (2): 525–536. doi:10.1016/S0896-6273(01)00302-6...

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Period circadian protein homolog 1

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tropicalis) PER1 (Equus caballus) PER1 (Macaca mulatta) PER1 (Sus scrofa) PER2 PER3 The human PER1 gene is located on chromosome 17 at the following location:...

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Transcription translation feedback loop

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duplication, of the period gene in mammals listed as mPer1, mPer2, and mPer3. There are also two paralogs of cryptochrome in mammals. PER and CRY proteins...

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North East New Territories New Development Areas Planning

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(CE)). Hong Kong: ARUP. Retrieved from http://www.nentnda.gov.hk/doc/pe/PER3_e.pdf 土地正義聯盟(2014年6月11日)。反東北懶人包之一:要求政府立即撤回新界東北發展計劃的十個理由。獨立媒體。2016年11月23日,取自http://www...

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